晚期喉癌术后患者行同期放化疗与单纯放疗的临床疗效比较及预后分析

发布时间：2018-04-06 03:35

本文选题：喉肿瘤　切入点：放射治疗　出处：《肿瘤防治研究》2014年05期

【摘要】：目的比较晚期喉癌患者喉全切或次全切术后行同期放化疗与单纯行放射治疗的临床疗效差异、探讨影响预后的相关因素。方法回顾性分析2007—2008年195例喉全切或次全切术后在郑州大学第一附属医院放疗科行放射治疗患者的临床病例资料,利用Kaplan-meier法、Log rank检验、Cox比例风险模型对患者生存率进行比较并分析影响预后的相关因素。结果 195例患者术后行同期放化疗5年生存率为68.2%,单纯放疗5年生存率为48.9%,差异有统计学意义;单因素分析结果显示:放疗剂量、年龄、治疗方案、肿瘤大小、肿瘤部位、术后至放疗结束时间、有无淋巴结转移是影响患者生存预后的因素;Cox回归分析示患者年龄、治疗方案、术后至放疗结束时间、有无淋巴结转移是影响预后的独立因素。结论年龄、治疗方案、术后至放疗结束时间、有无淋巴结转移是影响喉癌患者术后预后的独立因素。行放化疗综合治疗,术后11周内完成放射治疗计划,坚持随访,及时处理肿瘤复发、淋巴结转移有望提高生存率。
[Abstract]:Objective to compare the clinical efficacy of radiotherapy and radiotherapy in patients with advanced laryngeal cancer after total laryngectomy or subtotal laryngectomy.Methods the clinical data of 195 patients undergoing total laryngectomy or subtotal laryngectomy in the radiotherapy Department of the first affiliated Hospital of Zhengzhou University from 2007 to 2008 were retrospectively analyzed.The survival rate of the patients was compared with that of the Cox proportional hazard model by Kaplan-meier 's log rank test, and the related factors affecting the prognosis were analyzed.Results the 5-year survival rate of 195 patients was 68.2, and that of radiotherapy alone was 48.9. The results of univariate analysis showed that: dose, age, treatment plan, tumor size, tumor location, tumor size, tumor size, tumor site, tumor size, tumor size, tumor size, tumor size, and tumor location.From postoperative to the end of radiotherapy, lymph node metastasis was an important factor influencing the survival and prognosis of patients. Cox regression analysis showed that age, treatment plan, postoperative to radiotherapy end time and lymph node metastasis were independent factors of prognosis.Conclusion Age, treatment regimen, postoperative time to the end of radiotherapy, lymph node metastasis are independent factors for postoperative prognosis of laryngeal cancer patients.Radiotherapy and chemotherapy combined therapy were performed, radiotherapy plan was completed within 11 weeks after operation, follow up was persisted, tumor recurrence was dealt with in time, lymph node metastasis was expected to improve survival rate.
【作者单位】：河南省郑州大学第一附属医院放疗科;河南省登封市人民医院耳鼻喉科;郑州大学第一附属医院病理科;
【分类号】：R739.65

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