光学相干断层成像术在老年开角型青光眼视网膜神经纤维层厚度检测中的应用价值

发布时间：2018-04-06 03:40

本文选题：光学相干断层成像术　切入点：开角型青光眼　出处：《中国老年学杂志》2015年19期

【摘要】：目的探讨光学相干断层成像术(OCT)在老年开角型青光眼(POAG)视网膜神经纤维层厚度检测中的应用价值。方法选择初诊30例老年POAG患者为观察组,并根据病情的早期、进展期、晚期分为观察1组,2组,3组,另取30例正常人群作为对照组,予以所有研究对象常规眼科检查以及OCT检查,观察组进行视野检查。结果与对照组比较,观察1、2、3组的RNFL厚度测量中上方、下方、颞侧、鼻侧以及均值均降低明显(P0.05);观察组组间比较,与观察1组比较,观察2、3组的各项指标均降低明显(P0.05)。就OCT图像而言,对照组可见上、下极厚,其次为颞侧,鼻侧最薄,图像曲线表现为双峰形;POAG患者RNFL的早期可表现局限性的变薄或缺损,进展期则表现弥漫性变薄,晚期则表现为弥漫性变薄,且混合局限性缺损,视野检测的缺损均值与RNFL厚度呈负相关,尤以RNFL平均厚度相关性最大。结论 OCT以其可较好地区分RNFL厚度而用于老年POAG的诊断之中,且随着病程的发展,RNFL厚度逐渐变薄,视野的平均缺损范围则渐趋增加。
[Abstract]:Objective to evaluate the value of optical coherence tomography (Oct) in detecting the thickness of retinal nerve fiber layer (RNFL) in aged patients with open-angle glaucoma (POAGG).Methods A total of 30 elderly POAG patients were selected as the observation group and divided into three groups according to the early stage and advanced stage of the disease. Another 30 normal persons were taken as the control group.All subjects were given routine ophthalmologic examination and OCT examination, and the observation group underwent visual field examination.Results compared with the control group, the thickness of RNFL was significantly decreased in the upper, lower, lower temporal, nasal and average sides of the three groups, and compared with the control group, all the indexes of the observation group were significantly lower than those of the observation group 1 (P 0.05), and that of the control group was significantly lower than that of the control group (P < 0.05), while that of the control group was significantly lower than that of the control group (P < 0.05).As far as OCT images were concerned, in the control group, the upper and lower sides were thicker, the temporal side was the second, the nasal side was the thinnest. The image curve showed that the RNFL of the patients with bimodal Poag showed local thinning or defect at the early stage, and diffuse thinning at the advanced stage.In the later stage, diffuse thinning and mixed local defect were observed. The mean value of visual field defect was negatively correlated with the thickness of RNFL, especially the average thickness of RNFL.Conclusion OCT can be used in the diagnosis of senile POAG because it can distinguish the thickness of RNFL well. With the development of the course of disease, the thickness of OCT becomes thinner, and the average defect area of visual field increases gradually.
【作者单位】：华中科技大学同济医学院附属普爱医院眼科;华中科技大学同济医学院附属普爱医院中医科;
【基金】：武汉市临床医学科研项目(WZ14B08)
【分类号】：R775

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