曲安奈德局部注射治疗Mikulicz’s病的临床研究

发布时间：2018-04-09 09:35

本文选题：Mikulicz’s病　切入点：曲安奈德　出处：《中国现代医学杂志》2014年10期

【摘要】：目的探讨曲安奈德局部注射治疗Mikulicz’s病的临床疗效和副作用。方法回顾性分析21例经临床、影像学检查或病理结果证实的Mikulicz’s病患者病历资料,全部患者均行眼眶CT或B型超声检查,在得到临床和病理学确诊后,采用分次曲安奈德针眼眶局部注射,观察记录治疗效果和不良反应情况,并在疗程结束后6个月~7年评估其近远期疗效。结果 21例经曲安奈德局部注射的患者中,15例在第1次注射后即见眼睑肿胀外观明显减轻,20例患者肿胀的泪腺均可在注射1疗程后完全消退。1例对激素治疗效果不佳者给予手术切除肿大病变。经治疗后的随访病例复发较少,复发者也较首次发作症状轻。21例局部注射患者中除对2例女性患者月经周期有轻微影响,但停药后恢复正常外,治疗期间未出现明显的不良反应,在近远期随访中复发病例较少。结论曲安奈德局部注射治疗Mikulicz’s病可取的较好的临床疗效,复发少,副作用小。
[Abstract]:Objective to investigate the clinical efficacy and side effects of triamcinolone acetonide injection in the treatment of Mikulicz's 's disease.Methods the medical records of 21 patients with Mikulicz's 's disease confirmed by clinical, imaging or pathological findings were retrospectively analyzed. All patients underwent orbital CT or B-mode ultrasonography.Intraorbital injection of triamcinolone acetonide was used to observe the therapeutic effects and adverse reactions and to evaluate the short-term and long-term effects from 6 months to 7 years after the treatment.Results in 21 cases of local injection of triamcinolone acetonide, 15 cases showed the appearance of eyelid swelling after the first injection. The swelling of lacrimal glands in 20 cases could be completely dissipated after one course of injection. 1 cases had the effect of hormone therapy.The poor were given surgical resection of the swelling and lesions.After treatment, there were fewer recurrence cases, and the recurrence cases were lighter than those of the first attack. In addition to 2 female patients, the menstrual cycle was slightly affected, but recovered to normal after withdrawal of the drug.There were no obvious adverse reactions during treatment, and there were fewer recurrence cases in short-and long-term follow-up.Conclusion Local injection of triamcinolone acetonide in the treatment of Mikulicz's 's disease is effective, with less recurrence and less side effects.
【作者单位】：中南大学湘雅医院眼科;
【分类号】：R593.2;R771.3

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