睡眠呼吸暂停进程中自主神经功能活动的变化趋势

发布时间：2018-04-11 06:25

本文选题：阻塞性呼吸暂停 + 中枢性呼吸暂停　；参考：《南京医科大学学报(自然科学版)》2013年06期

【摘要】：目的:探讨阻塞性与中枢性呼吸暂停进程中自主神经功能活动的特点。方法:对30例阻塞性睡眠呼吸暂停综合征患者进行整夜标准多导睡眠监测,选取睡眠呼吸事件发生期间及其前后各15 s的3个连续区间,提取各区间相应的RR间期变化的时间序列资料及其相关背景。分析比较阻塞性与中枢性呼吸事件进程中R-R间隔的变化趋势。结果:阻塞性呼吸暂停进程中RR间隔变异有明显差异,与呼吸暂停发生前相比较,RR的平均值、标准差和均方根在呼吸暂停期间最小,在呼吸暂停结束后增大。提示阻塞性呼吸暂停期RR间隔最短,心率变异最小,但整体波动较均一。而中枢性呼吸暂停进程中RR间隔无显著性变化。结论:阻塞性和中枢性呼吸暂停进程中自主神经功能活动的趋势不同。交感与副交感神经系统功能活动在阻塞性呼吸事件前后实现了2次交替,即交感活动在阻塞性呼吸事件发生过程中逐步增强而在其结束后逐步回复。而中枢性呼吸事件进程中则无此变化。
[Abstract]:Objective: to investigate the characteristics of autonomic nervous function in obstructive and central apnea.Methods: 30 patients with obstructive sleep apnea syndrome were monitored with standard polysomnography all night.The time series data of RR interval change in each interval and its related background were extracted.To analyze and compare the change trend of R-R interval between obstructive and central respiratory events.Results: there was significant difference in RR interval variation in the process of obstructive apnea. Compared with that before apnea, the standard deviation and root mean square (RMS) of RR were the smallest during apnea and increased after apnea.It suggested that the RR interval was the shortest and the heart rate variability was the least in obstructive apnea, but the whole fluctuation was more uniform.But there was no significant change in RR interval in the process of central apnea.Conclusion: the trend of autonomic nervous function in obstructive and central apnea processes is different.The function of sympathetic and parasympathetic nervous system alternates twice before and after the obstructive respiratory event, that is, the sympathetic activity increases gradually during the occurrence of obstructive respiratory event and then returns gradually after the end of the event.There was no such change in the process of central respiratory events.
【作者单位】：南京医科大学第一附属医院耳鼻咽喉科;日本滋贺医科大学睡眠医学教研室;
【基金】：江苏高校优势学科建设工程(PAPD2010-2013) 南京医科大学第一附属医院/江苏省人民医院创新团队工程(IRT-016) 江苏省“科教兴卫工程”医学重点学科基金(XK200719)开放课题(XK19200901) 教育部留学回国人员科研启动基金(20101174)
【分类号】：R56

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