小牛血去蛋白提取物眼用凝胶与玻璃酸钠滴眼液防治LASIK术后干眼疗效对比

发布时间：2018-04-11 06:08

本文选题：小牛血去蛋白提取物 + 玻璃酸钠　；参考：《眼科新进展》2014年07期

【摘要】：目的比较小牛血去蛋白提取物眼用凝胶和1 g·L-1玻璃酸钠防治准分子激光原位角膜磨镶术(laser in situ keratomileusis,LASIK)术后干眼的疗效。方法将拟行LASIK的近视患者120例(240眼)随机分为A、B两组,术后分别使用小牛血去蛋白提取物眼用凝胶、1 g·L-1玻璃酸钠眼液,每天4次滴眼,术后1周、2周和4周对2组患者进行眼表疾病指数问卷调查(ocular surface disease index,OSDI)评分,记录患者的视力和屈光度,进行泪液分泌试验、泪膜破裂时间检查及眼表荧光素染色检查。结果术后不同时间两组患者视力和屈光度无明显差别(均为P0.05)。术后1周A组OSDI评分较低(P0.05),其他时间点两组间没有明显差别(均为P0.05);A组术后眼部不适对日常生活的影响始终低于B组(P0.05);两组术后因环境因素诱发眼部不适的情况无明显差别(P0.05)。A组术后不同时间泪膜破裂时间均长于B组(均为P0.05),但两组间的泪液分泌试验结果无明显差别(均为P0.05)。A组术后不同时间角膜荧光素染色评分均低于B组(均为P0.01)。结论质量分数20%小牛血去蛋白提取物眼用凝胶治疗LASIK术后干眼比1 g·L-1玻璃酸钠起效快,疗效更好,更适于LASIK术后使用。
[Abstract]:Objective to compare the effects of ophthalmic gel and 1 g L-1 sodium hyaluronate in the treatment of dry eyes after laser in situ keratomileusis (LASK).Methods one hundred and twenty patients (240 eyes) with LASIK were randomly divided into two groups: group A (n = 20) and group A (n = 20). After operation, 1 g L ~ (-1) sodium hyaluronate eye solution was used as the extract of calf blood deproteinization respectively, and the eyes were dripped 4 times a day.Visual acuity and diopter were recorded, tear secretion test, lacrimal film rupture time and fluorescein staining were performed 1 week and 4 weeks after operation.Results there was no significant difference in visual acuity and diopter between the two groups at different time after operation (P 0.05).At 1 week after operation, the OSDI score of group A was lower than that of group A (P 0.05), but there was no significant difference between the two groups at other time points (both P0.05A group had lower influence on daily life than group B, and the postoperative ocular discomfort induced by environmental factors in both groups was lower than that in group B).The tear film rupture time of group A was longer than that of group B at different time after operation (P 0.05), but there was no significant difference in the results of tear secretion test between the two groups (P 0.05). The score of corneal fluorescein staining in group A was lower than that in group B at different time after operation (all P 0.01).Conclusion the gel of 20% calf blood deproteinized extract is more effective than 1 g L -1 sodium hyaluronate in the treatment of dry eye after LASIK, and is more suitable for LASIK operation.
【作者单位】：承德医学院附属医院眼科;
【基金】：河北省科技支撑计划项目(编号:200922084)~~
【分类号】：R779.6

【参考文献】