OSAHS合并高血压患者血糖、血脂的相关性研究

发布时间：2018-04-13 18:53

本文选题：阻塞性睡眠呼吸暂停低通气综合征 + 血糖　；参考：《新疆医科大学》2011年硕士论文

【摘要】：目的：探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)合并高血压患者及其与血糖、血脂的相关性。方法：回顾性搜集了PSG诊断排除OSAHS(阻塞性睡眠呼吸暂停低通气综合征)患者120例(其中健康对照组60例,高血压患者60例),确诊为OSAHS120例(单纯OSAHS患者60例,合并高血压患者60例)患者的血清空腹血糖、糖化血红蛋白、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)及呼吸暂停低通气指数(AHI)、最低血氧饱和度(LSO2)、平均血氧饱和度(BSO2)监测结果,探讨各指标与OSAHS的相关性。结果：方差分析结果示OSAHS合并高血压患者上述指标与单纯OSAHS患者组、高血压患者组及对照组有显著差别,线性相关分析显示LSaO2、MSaO2与A HI成负相关(r分别为-0.710,-0.560,均P0.01)。OSAHS患者血清空腹血糖、糖化血红蛋白、TG、TC、LDL与AHI呈正相关(r=0.123、0.310、0.521、0.698、0.799,P0.05或P0.01),HDL与AHI呈负相关(r分别为-0.652,P0.01)。结论：空腹血糖、糖化血红蛋白、TG、TC、LDL水平与AHI相关;OSAHS可影响患者的糖代谢,导致糖化血红蛋白升高,预示糖尿病及微血管病变的发生乱相关,同时高血压患者血脂水平升高,OSAHS患者血脂水平升高,两者比较,OSAHS合并高血压患者血脂水平较健康对照及分别患有两种疾病之一的水平要高,可见OSAHS可影响患者血脂水平,同时促进高血压的发生。
[Abstract]:Objective: to investigate the relationship between obstructive sleep apnea hypopnea syndrome (OSAHS) with hypertension and blood glucose and blood lipid.Methods: one hundred and twenty patients with obstructive sleep apnea hypopnea syndrome (OSAHS) diagnosed by PSG were retrospectively collected, including 60 healthy control group, 60 hypertension patients and 60 OSAHS120 patients.Serum fasting blood glucose, glycosylated hemoglobin,The monitoring results of TGG, TC, HDL, LDL, LDL and apnea hypopnea index (AHIHV), minimum oxygen saturation (LSO _ 2) and mean oxygen saturation (BSO _ 2) were observed. The correlation between the indexes and OSAHS was discussed.Results: the results of ANOVA showed that the above indexes in OSAHS patients with hypertension were significantly different from those in patients with OSAHS alone, hypertension patients and control groups.The linear correlation analysis showed that the negative correlation r between MSaO2 and HI was -0.710 ~ (-0.560), respectively. The serum fasting blood glucose (FBG), glycosylated hemoglobin (HbAc) TGG / TC-LDL and AHI were positively correlated with AHI (r = -0.123) 0.3102n 0.698U 0.799P0.05 or P 0.01HDL negatively correlated with AHI, r = -0.652g / P0.01a, respectively.Conclusion: the levels of fasting blood glucose, glycosylated hemoglobin (TGG) TCU LDL and AHI associated with OSAHS may affect the glucose metabolism of patients and lead to the increase of glycosylated hemoglobin, indicating the disorder correlation between diabetes mellitus and microangiopathy.At the same time, the level of blood lipid in patients with hypertension was higher than that in patients with hypertension. The level of serum lipids in patients with hypertension was higher than that in healthy controls and patients with one of the two diseases. It can be seen that OSAHS can affect the level of blood lipid in patients with hypertension.At the same time promote the occurrence of hypertension.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R766

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