高海拔地区非颞动脉炎性前部缺血性视神经病变的发病因素与临床相关性研究

发布时间：2018-04-30 13:58

本文选题：高海拔 + 非颞动脉炎性前部缺血性视神经病变　；参考：《青海大学》2013年硕士论文

【摘要】：目的：探讨高海拔地区非颞动脉炎性前部缺血性视神经病变(NAION)的发病因素与临床的相关研究。方法:2011年3月-2012年9月期间来我科门诊就诊，，并确诊为NAION的住院患者纳为病例组。并将同一时期来我院参加门诊体检并与病例组年龄、性别相匹配的人群作为对照组。 1).将纳入对象的个人资料进行详细登记。 2).对纳入对象进行详尽的眼科检查。 3).对纳入对象进行血压监测及血常规、血脂、血糖、血液流变学等化验检查,并将观察指标详细记录；结果：1).NAION组与对照组之间总胆固醇、HDL-脂蛋白、血常规无显著性差异(P＞0.05)，而甘油三脂、血糖、血压有显著性差异(P＜0.05)，NAION组较高。 2).全血粘度高切、血浆粘度、全血还原粘度中切、红细胞变形指数、血沉、血沉方程K值二组之间无显著性差异(P＞0.05),而全血黏度中低切、红细胞压积、全血还原粘度高低切、红细胞聚集指数有显著性差异(P＜0.05),NAION组较高。结论：1).高海拔地区NAION的发病因素不是单一的,是多因素相互作用的结结果。 2).高海拔低压低氧等环境条件下，NAION的发病与人体微循环发生的一系列病理生理变化相关。 3).甘油三脂、血压、血糖对高海拔地区NAION的发生具有统计学意义。 4).高血粘度是高海拔地区NAION的发生的危险因素。 5).加强高海拔地区人群对NAION的健康教育，提高其对NAION防治的认识。
[Abstract]:Objective: to investigate the risk factors of nontemporal inflammatory anterior ischemic optic neuropathy (NAION) in high altitude area. A clinical study. Methods: from March 2011 to September 2012, inpatients diagnosed as NAION were admitted to our outpatient clinic as the case group. At the same time, the people who came to our hospital to attend outpatient examination and matched the age and sex of the case group were taken as the control group. 1. Register the personal data of the object in detail. 2. A detailed ophthalmic examination was carried out on the subjects involved. Three. Blood pressure monitoring, blood routine, blood lipid, blood sugar, hemorheology and other laboratory tests were carried out, and the observation indexes were recorded in detail. Results there was no significant difference in blood routine between the two groups (P > 0.05), but there was significant difference in triglyceride, blood glucose and blood pressure between the two groups (P < 0.05). 2. There was no significant difference in whole blood viscosity, plasma viscosity, whole blood reductive viscosity, erythrocyte deformability index, erythrocyte sedimentation equation K value between the two groups (P > 0.05), but the whole blood viscosity was low shear, hematocrit, whole blood reductive viscosity high and low shear. There was significant difference in erythrocyte aggregation index (P < 0.05). Conclusion 1: 1. The pathogenesis of NAION in high altitude area is not single, it is the result of multi-factor interaction. 2. The pathogenesis of NAION is related to a series of pathophysiological changes of human microcirculation at high altitude, low pressure and hypoxia. Three. Triglyceride, blood pressure and blood sugar were statistically significant in the occurrence of NAION at high altitude. 4. High blood viscosity is the risk factor of NAION in high altitude area. Five. To strengthen the health education of NAION in high altitude area and to improve their understanding of NAION prevention and treatment.
【学位授予单位】：青海大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R774.6

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