原发性开角型青光眼和2型糖尿病的关系探讨

发布时间：2018-04-30 21:32

本文选题：原发性开角型青光眼 + 2型糖尿病　；参考：《新疆医科大学》2014年硕士论文

【摘要】：目的：探讨原发性开角型青光眼(POAG)和2型糖尿病的关系。方法：收集113例POAG患者的病历资料,其中21例(40只眼)合并2型糖尿病患者分为糖尿病组,92例(172只眼)单纯POAG患者分为非糖尿病组,分析比较两组的视力、眼压、视野平均缺损(MD)、视网膜神经纤维层(RNFL)厚度及眼底杯盘比(C/D)差异。结果：在113例POAG患者中,非糖尿病组和糖尿病组在不同年龄段(小于40岁、40-60岁、大于60岁)和性别的差异无统计学意义(P0.05)；非糖尿病组的视力均值(0.37±0.28)和糖尿病组的视力均值(0.38±0.27)的差异无统计学意义(P0.05)；非糖尿病组眼压均值(20.67±4.99)mmHg和糖尿病组眼压均值(20.93±3.99)mmHg的差异无统计学意义p0.05)；非糖尿病组视野MD均值(-9.23-2.99)dB和糖尿病组视野MD均值(-10.89±2.96)dB的差异有统计学意义(P0.05)；非糖尿病组RNFL厚度均值(92.86±12.84)μm和糖尿病组RNFL厚度均值(86.29±11.29)μmm之间差异有统计学意义(P0.05)；非糖尿病组眼底C/D均值(0.56±0.17)和糖尿病组眼底C/D均值(0.56±0.15)之间差异无统计学意义(P0.05)；非糖尿病组视野MD和RNFL厚度呈负相关(相关系数为-0.780,P0.05)：糖尿病组视野MD和RNFL厚度呈负相关(相关系数-0.729,P0.05)。结论：原发性开角型青光眼合并2型糖尿病者视野的缺损和视网膜神经纤维层的损害更加严重,但对视力、眼压及杯盘比的影响不显著。
[Abstract]:Objective: to investigate the relationship between primary open angle glaucoma (Poag) and type 2 diabetes. Methods: the medical records of 113 patients with POAG were collected. Among them, 21 cases (40 eyes) with type 2 diabetes mellitus were divided into diabetic group (92 cases) and 172 eyes) POAG patients were divided into non-diabetic group. The visual acuity and intraocular pressure (IOP) of the two groups were analyzed and compared. The mean visual field defect (MD), retinal nerve fiber layer (RNFL) thickness and fundus cup / disc ratio (C / D) were different. Results: among the 113 patients with POAG, the non-diabetic group and the diabetic group were in different age groups (< 40 years old and 40 to 60 years old). There was no significant difference in visual acuity between the non-diabetic group (0.37 卤0.28) and the diabetic group (0.38 卤0.27), the mean intraocular pressure (IOP) was 20.67 卤4.99)mmHg in the non-diabetic group and 20.93 卤3.99)mmHg in the diabetic group. There was no significant difference in RNFL thickness between non-diabetic group and diabetic group (P < 0.05), and there was significant difference between non-diabetic group and diabetic group (P < 0.05). There was a significant difference between non-diabetic group and diabetic group in RNFL thickness (92.86 卤12.84) 渭 m and diabetes group (86.29 卤11.29) 渭 mm respectively. There was no significant difference between non-diabetic group and diabetic group (P 0.05). There was a negative correlation between MD and RNFL thickness in non-diabetic group (correlation coefficient was -0.780 P 0.05): in diabetic group, MD and RNFL in visual field were significantly lower than that in non-diabetic group (P < 0.05), and the correlation coefficient was -0.780 P 0.05 (P < 0.05), and there was no significant difference between non-diabetic group and diabetic group (P < 0.05), and the correlation coefficient was -0.780 P 0.05 (correlation coefficient = -0.780 P 0.05; P < 0.05). The thickness was negatively correlated (correlation coefficient -0.729, P 0.05). Conclusion: the visual field defect and retinal nerve fiber layer damage in patients with primary open-angle glaucoma complicated with type 2 diabetes are more serious, but the effects on visual acuity, intraocular pressure and cup / disc ratio are not significant.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R775.2

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