垂体生长激素腺瘤合并阻塞性睡眠呼吸暂停低通气综合征及睡眠低氧的危险因素

发布时间：2018-05-12 14:05

本文选题：垂体生长激素腺瘤 + 肢端肥大症　；参考：《南方医科大学学报》2015年10期

【摘要】：目的探讨垂体生长激素(GH)腺瘤合并阻塞性睡眠呼吸暂停低通气综合征(OSAHS)及睡眠低氧(SH)的危险因素。方法严格按照入组及排除标准选取85例垂体GH腺瘤患者,所有患者入院后均行睡眠呼吸监测。收集患者的临床资料、化验结果、影像资料进行对比分析,并采用二元logistic回归分析相关危险因素。结果该组垂体生长激素腺瘤患者合并OSAHS的发生率为62.4%(53/85),合并SH的发生率为75.3%(64/85)。进行回归分析得出年龄(OR=1.107)及BMI(OR=1.166)为OSAHS的危险因素,BMI(OR=1.334)为SH的危险因素。结论高龄及BMI增加是垂体GH腺瘤患者合并OSAHS及SH的独立危险因素。术前常规行睡眠呼吸监测,早期识别患者并指导患者保持健康体重,是降低患者呼吸系统相关死亡率的有效方法。
[Abstract]:Objective to investigate the risk factors of pituitary growth hormone (GH) adenoma with obstructive sleep apnea hypopnea syndrome (OSAHS) and sleep hypoxic (SH). Methods 85 patients with pituitary GH adenoma were selected strictly according to the entry group and exclusion criteria. All patients were monitored by sleep apnea after admission. The clinical data, test results, and images were collected. The data were compared and analyzed with two yuan logistic regression analysis. Results the incidence of OSAHS in patients with pituitary growth hormone adenoma was 62.4% (53/85), and the incidence of SH was 75.3% (64/85). The risk factors of age (OR=1.107) and BMI (OR=1.166) as OSAHS were analyzed by regression analysis, BMI (OR=1.334) was SH. Conclusion the increase of age and BMI is an independent risk factor for the combination of OSAHS and SH in patients with pituitary GH adenoma. Routine sleep breathing monitoring before operation, early identification of patients and guiding the patients to maintain healthy weight are effective methods to reduce the mortality related to respiratory system.

【作者单位】：中国医学科学院北京协和医学院北京协和医院神经外科;
【分类号】：R766;R736.4

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