青少年近视调节刺激反应及M-受体阻断剂对调节影响的研究

发布时间：2018-05-15 19:39

本文选题：近视 + 调节刺激反应　；参考：《复旦大学》2010年硕士论文

【摘要】： 第一部分青少年近视与正视调节刺激反应差异的研究目的探讨青少年近视与正视调节刺激反应的差异。方法163名5岁～15岁青少年佩戴全矫框架镜,163人在单眼视状态下,其中24人也同时在双眼视状态下,利用开放视野自动验光仪WAM-5500测量右眼注视分别位于6.0m、0.5m、0.33m、0.25m、0.20 m距离视标的调节刺激反应。结果1、近视组调节刺激反应曲线斜率显著低于正视组(p=0.042)；2、不同程度近视组调节刺激反应曲线斜率与正视组比较(F=28.14,P=0.000)：正视组与轻度、高度近视组无显著性差异(p=0.135,p=0.957),正视组与中度近视组有显著性差异(p=0.000),轻度、中度、高度近视组间比较无显著性差异(p0.05)；3、双眼视与单眼视间调节刺激反应曲线斜率差异无统计学意义(p=0.085) 结论调节刺激反应降低与早发性近视间存在一定联系,调节刺激反应不随近视程度加深而降低。双眼调节准确性不显著优于单眼。第二部分消旋山莨菪碱对调节和瞳孔的影响目的观察0.5%消旋山莨菪碱对调节及瞳孔的影响。方法44名受试者(7～17岁)分为美多丽组及消旋山莨菪碱组,用开放视野自动验光仪WAM-5500测量右眼注视分别位于6.0m、0.5m、0.25m、0.17 m距离视标干预前后调节刺激反应。Visante OCT测量消旋山莨菪碱组在0、-2D、-4D、-6D调节状态下干预前后右眼眼前节生物学指标的变化。结果美多丽组干预前后调节刺激反应曲线斜率变化有统计学意义(t=15.281,p=0.000),消旋山莨菪碱组无统计学差异(t=1.865,p=0.692)；消旋山莨菪碱组在0、-4D、-6D调节时干预后瞳孔直径大于干预前(p=0.022、p=0.007、P=0.006)；0、-2D、-6D调节时干预前后晶体厚度差异无统计学意义(p=0.303、p=0.168、p=0.230),0、-2D、-4D、-6D调节时干预前后前房深度差异无统计学意义(p=0.681、p=0.376、p=0.468、p=0.876)。结论0.5%消旋山莨菪碱有扩瞳作用,调节麻痹作用极弱。
[Abstract]:The first part: a study on the difference between myopia and emmetropia response in adolescents Objective to explore the difference between myopia and emmetropia in adolescents. Methods 163 adolescents aged from 5 to 15 years old were treated with full orthopedic frame lens, 163 were in monocular condition, 24 of them were also in binocular vision. Open field automatic optometry (WAM-5500) was used to measure the stimulus response of right eye fixation at a distance of 6.0mg 0.33mt 0.25m / 0.20m respectively. Results 1. The slope of regulatory stimulus response curve in myopia group was significantly lower than that in emmetropia group. The slope of regulatory stimulus response curve in myopia group was significantly lower than that in emmetropia group and emmetropia group, and the slope of regulatory stimulus response curve in myopia group was significantly lower than that in emmetropia group and emmetropia group. There was no significant difference between the high myopia group and the middle myopia group. There was no significant difference between the light, moderate and high myopia groups. There was no significant difference between the two groups. There was no significant difference in the slope of the stimulus response curve between the binocular and monocular eyes. Conclusion there is a certain relationship between the decrease of regulatory stimulus response and early onset myopia, and the regulatory stimulus response does not decrease with the deepening of myopia. The accuracy of binocular adjustment was not significantly better than that of monocular. Part two effects of racemic anisodamine on regulation and pupil Objective to observe the effect of 0.5% racemic anisodamine on regulation and pupil. Methods 44 subjects, aged 7 to 17, were divided into two groups: Meridoli group and racemic anisodamine group. Open field automatic optometry (WAM-5500) was used to measure the changes of biological indexes of right eye anterior ganglion before and after the intervention of the right eye fixation at a distance of 6.0mU 0.5m-1 0.25mL 0.17m. Visante OCT was used to measure the biological indexes of right eye anterior ganglia before and after the intervention of the racemic anisodamine group under the control state of 0 ~ 2D ~ (-4D) -4D ~ (-6D). Results before and after intervention, the slope of regulatory response curve in Medolia group was significantly higher than that in scopolamine group, but there was no statistical difference in the racemic anisodamine group, and the pupil diameter in the racemic anisodamine group was larger than that in the control group before and after intervention. There was no significant difference in lens thickness before and after intervention. There was no significant difference in anterior chamber depth before and after intervention. Conclusion 0.5% racemic anisodamine has pupil dilatation and very weak palsy regulation.
【学位授予单位】：复旦大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R778.1

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