孟鲁司特钠联合布地奈德鼻喷剂治疗变应性鼻炎的疗效及对患者血清炎性因子的影响

发布时间：2018-05-18 14:24

本文选题：变应性鼻炎 + 孟鲁司特钠　；参考：《北方药学》2015年02期

【摘要】：目的:探讨孟鲁司特钠联合布地奈德鼻喷剂治疗变应性鼻炎的疗效及对患者血清炎性因子的影响。方法:选择2013年6月~2014年6月在我院接受治疗的变应性鼻炎患者110例。将所有患者按照治疗方法分为两组,对照组应用布地奈德鼻喷剂予以治疗,观察组在对照组治疗的基础上加用孟鲁司特钠进行治疗。治疗3周后,比较两组的临床疗效及血清炎性因子的变化。结果:观察组治疗效果明显优于对照组,差异显著,有统计学意义(P0.05);治疗3周后,和治疗前相比,两组疗效显著,血清IL-6、IL-8水平有明显降低,观察组IL-10水平明显升高,差异显著(P0.05),有统计学意义;两组相比,观察组临床疗效明显优于对照组,血清IL-6、IL-8水平明显降低,IL-10水平升高,差异显著(P0.05),有统计学意义。结论:采用孟鲁司特钠联合布地奈德鼻喷剂治疗变应性鼻炎,临床疗效显著,可有效降低血清IL-6和血清IL-8水平,提高血清IL-10水平,值得临床推广。
[Abstract]:Objective: to investigate the effect of montelukast sodium combined with budesonide nasal spray on allergic rhinitis and its effect on serum inflammatory factors. Methods: 110 cases of allergic rhinitis treated in our hospital from June 2013 to June 2014 were selected. All the patients were divided into two groups according to the treatment method, the control group was treated with budesonide nasal spray, and the observation group was treated with montelukast sodium on the basis of the control group. After 3 weeks of treatment, the clinical efficacy and changes of serum inflammatory factors were compared between the two groups. Results: the therapeutic effect of the observation group was significantly better than that of the control group, and the difference was statistically significant (P 0.05). After 3 weeks of treatment, compared with before treatment, the therapeutic effect of the two groups was significant, the level of serum IL-6 and IL-8 was significantly decreased, and the level of IL-10 in the observation group was significantly increased. Compared with the control group, the clinical efficacy of the observation group was significantly better than that of the control group, and the level of serum IL-6 + IL-8 was significantly lower than that of the control group, and the difference was significant (P 0.05). Conclusion: the clinical effect of montelukast sodium combined with budesonide nasal spray on allergic rhinitis is remarkable. It can effectively reduce serum IL-6 and serum IL-8 level and increase serum IL-10 level.
【作者单位】：广东省云浮市人民医院耳鼻咽喉头颈外科;
【分类号】：R765.21

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