平阳霉素治疗眼眶低流速静脉畸形的临床研究

发布时间：2018-05-22 08:37

本文选题：平阳霉素 + 眼眶　；参考：《上海交通大学》2014年博士论文

【摘要】：目的：探讨病灶内注射平阳霉素治疗眼眶低流速静脉畸形的疗效与安全性，总结临床经验，进而指导临床工作。方法：回顾性分析2002年－2013年间上海交通大学医学院附属第九人民医院眼科的33例(33眼)行病灶内平阳霉素注射治疗的眼眶低流速静脉畸形患者临床资料，记录病变部位、初次接受该治疗的年龄、治疗次数、剂量、随访时间，比较治疗前后情况，包括病变体积、青紫程度、高出皮面情况等；评估与平阳霉素相关副作用的发生情况。结果：本项目眼眶低流速静脉畸形患者的年龄范围4-45岁(平均23.8±11.2岁)，其中男性18例(54.5%)，女性15例(45.5%)；其中17例（51.5%）位于上、下眼睑、9例(27.3%)累及结膜、4例(12.1%)位于肌锥内、2例(6.1%)位于眉弓、1例(3.0%)位于内眦部。随访时间2-48月（平均7.9±8.2月）。患者病灶内注射平阳霉素平均次数为2±1次；术前病灶平体积为4.4cm3，术后为1.0cm3(t=4.63, P 0.001),体积平均缩小84.4%(28%-100%);94%的患者病变体积显著缩小，其中，浅表型病变显著缩小的比例为94.7%(18/19)，深部病变100%(3/3)，，混合病变90.9%(10/11)。术后患者外观包括病变青紫程度及高出皮面厚度较术前均有显著改善，随访未发现复发病例。治疗相关的副作用有术后短期内局部结膜水肿及局部皮下萎缩。结论：病灶内注射平阳霉素可作为眼眶低流速静脉畸形一线治疗方法
[Abstract]:Objective: to investigate the efficacy and safety of intrafocal injection of pingyangmycin in the treatment of orbital low-flow venous malformation. Methods: the clinical data of 33 cases (33 eyes) of orbital low velocity venous malformation treated with pingyangmycin injection from 2002 to 2013 were retrospectively analyzed, and the location of the lesions was recorded. The age, times, dosage and follow-up time of the treatment were compared before and after treatment, including volume of lesion, degree of cyanotic color, higher appearance of skin, etc. The occurrence of side effects associated with pingyangmycin was evaluated. Results: the age range of patients with orbital low flow venous malformation was 4 to 45 years old (mean 23.8 卤11.2 years old). 9 cases of inferior eyelid palpebrae were involved in conjunctiva in 4 cases (12.1) and 2 cases were located in musculocones, 2 cases were located in the middle of musculocones, 1 case was located in the middle part of the medial canthus, 1 case was located in the arch of the eyebrow, and 1 case was located in the middle canthus. The follow-up time was 2 to 48 months (mean 7.9 卤8.2 months). The mean intratumoral injection of pingyangmycin was 2 卤1, and the mean volume of pingyangmycin was 4.4cm ~ (-3) before operation and 1.0cm ~ (-3) after operation (P 0.001). The mean volume of pingyangmycin was reduced by 84.4% -100% (P < 0.05). The proportion of superficial lesions significantly reduced was 94.7 / 18 / 19, deep lesions 100 / 3 / 3, mixed lesions 90.9% / 10 / 11%. The appearance of the patients, including the degree of cyanotic lesions and the thickness of the skin, were significantly improved compared with those before operation, and no recurrence cases were found at the follow-up. Treatment-related side effects include local conjunctival edema and subcutaneous atrophy in the short term after operation. Conclusion: injection of pingyangmycin into the focus can be used as a first-line method for the treatment of orbital low velocity venous malformation.
【学位授予单位】：上海交通大学
【学位级别】：博士
【学位授予年份】：2014
【分类号】：R777.5

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