阻塞性睡眠呼吸暂停低通气综合征与高血压关系的前瞻性研究

发布时间：2018-05-30 16:50

本文选题：阻塞性睡眠呼吸暂停低通气综合征 + 高血压　；参考：《福建医科大学》2011年硕士论文

【摘要】：目的本课题旨在对阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea-hypopnea syndrome,OSAHS)患者进行为期3年的前瞻性随访观察,以明确睡眠呼吸暂停低通气指数(AHI)、最低血氧饱和度(MinSpO2)是否为高血压的独立危险因素,进一步探讨OSAHS与高血压的相关性。方法对在我科进行多导睡眠呼吸监测的692名无高血压患者进行前瞻性随访,其中OSAHS患者514例为病例组,无OSAHS患者(AHI5次/小时)178例为对照组;观察3年间高血压发病率情况,同时以高血压为结局变量进行多元Logistic回归分析AHI、MinSpO_2是否是高血压的独立危险因素。结果 1、共610名受试者完成3年随访,失访率11.8%,其中OSAHS患者450例,对照组160例。2、OSHAS患者的高血压病患病率28.4%,发病率9.6%;对照组的高血压病患病率17.5%,发病率5.4%,相对危险度(RR)值为1.778。3、以高血压为结局变量,以AHI、BMI、MinSpO2、年龄、性别、吸烟史、饮酒史、高血压家族史、nCPAP治疗情况为自变量的多元Logistic回归分析示AHI、BMI、MinSpO2、年龄进入模型,X~2 =57.956,P0.01,年龄、AHI、BMI、MinSpO2与高血压有统计学相关性。结论 AHI、MinSpO2是独立于年龄、性别、体重指数、吸烟与饮酒的高血压危险因素,OSAHS在高血压的发病中可能起着重要作用。
[Abstract]:Purpose The purpose of this study was to study the prospective follow-up of patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) with obstructive sleep apnea hypopnea syndrome (OSAHS) for 3 years. To determine whether sleep apnea hypopnea index (AHI) and minimum oxygen saturation (MOS) are independent risk factors of hypertension, and to further explore the correlation between OSAHS and hypertension. Method A prospective follow-up study was conducted in 692 patients with no hypertension who underwent polysomnography monitoring in our department, including 514 patients with OSAHS and 178 patients without OSAHS as control group. At the same time, multivariate Logistic regression analysis was performed with hypertension as outcome variable. Result 1. A total of 610 subjects were followed up for 3 years. The missing rate was 11.8. among them, 450 cases were OSAHS patients. In the control group, the prevalence of hypertension was 28.4 and the incidence rate was 9.60.The prevalence rate of hypertension in the control group was 17.5, the incidence rate was 5.4, the relative risk was 1.778.3, and the outcome variable was AHIBMIA MinSpO2, age, sex, smoking history, drinking history. Multivariate Logistic regression analysis showed that AHIBMIP MinSpO2 was associated with hypertension by multivariate Logistic regression analysis. The age entry model was 57.956 (P0.01), and the age of AHIBMI-MinSpO2 was significantly correlated with hypertension. Conclusion AHIHI-MinSpO2 is a risk factor for hypertension independent of age, sex, body mass index, smoking and alcohol consumption. OSAHS may play an important role in the pathogenesis of hypertension.
【学位授予单位】：福建医科大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R766

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