鼻咽癌及转移淋巴结扩散加权成像ADC值的测量和诊断价值研究

发布时间：2018-05-31 16:08

  本文选题：核磁共振 + 扩散加权成像　； 参考：《广西医科大学》2011年硕士论文

【摘要】：目的探讨磁共振加权成像及ADC值对鼻咽癌的诊断价值。 材料与方法研究对象为广西医科大学第一附属医院2010年5月至2011年1月初诊且经纤维鼻咽镜活检确诊鼻咽癌患者53例均行常规MR及增强扫描,单次激发自旋回波平面回波扩散加权成像,b值取1000s/mm~2,正常组行常规MR及DWI扫描;测量患者鼻咽癌原发灶、鼻咽癌转移淋巴结与正常人淋巴结的表观扩散系数(ADC)值;使用SPSS13.0统计学软件包对数据进行方差分析和配对t检验,P0.05为差异有统计学意义。 结果DWI图对肿块型鼻咽癌显示清晰,但对黏膜型鼻咽癌显示不佳,对转移淋巴结检出率为100%。鼻咽癌、转移淋巴结和正常淋巴结ADC值分别为0.799±0.157×10~(-3)mm~2/s、0.850±0.128×10~(-3)mm~2/s、1.039±0.165×10~(-3)mm~2/s。鼻咽癌与转移淋巴结的平均ADC值差异无统计学意义,鼻咽癌及转移淋巴结平均ADC值与正常淋巴结平均ADC值差异有统计学意义且两者平均ADC值均低于正常淋巴结平均ADC值。当b=1000s/mm~2,ADC阈值取0.844×10~(-3)mm~2/s时,鉴别鼻咽癌与正常淋巴结的敏感性为94.6%,特异性为72.5%;当ADC阈值取0.840×10~(-3)mm~2/s时,鉴别转移淋巴结与正常淋巴结的敏感性为97.3%,特异性为75%。 结论磁共振扩散加权成像及ADC值的测量对鼻咽癌及其转移淋巴结有一定的诊断价值。
[Abstract]:Objective to evaluate the diagnostic value of magnetic resonance weighted imaging (MRI) and ADC value in nasopharyngeal carcinoma (NPC). Materials and methods from May 2010 to January 2011, 53 patients with nasopharyngeal carcinoma (NPC) confirmed by fiberoptic nasopharyngoscope biopsy in the first affiliated Hospital of Guangxi Medical University underwent conventional and enhanced Mr scans. Single excitation spin echo plane echo diffusion weighted imaging was performed at 1000s / mm ~ (-2), and normal group was performed conventional Mr and DWI scans, and the apparent diffusion coefficient (ADCC) of metastatic lymph nodes of nasopharyngeal carcinoma (NPC), metastatic lymph nodes of nasopharyngeal carcinoma (NPC) and normal lymph nodes were measured. SPSS13.0 statistical software package was used to analyze the variance of data and paired t test (P0.05). Results DWI showed clearly in lumped nasopharyngeal carcinoma, but not in mucosal nasopharyngeal carcinoma. The detection rate of metastatic lymph node was 100%. The ADC values of nasopharyngeal carcinoma, metastatic lymph nodes and normal lymph nodes were 0.799 卤0.157 脳 10 ~ (-3) mm ~ (-1) and 0.850 卤0.128 脳 10 ~ (10) ~ (-3) mm ~ (-1) / s respectively. There was no significant difference in mean ADC value between nasopharyngeal carcinoma and metastatic lymph nodes. The mean ADC value of nasopharyngeal carcinoma and metastatic lymph nodes was significantly different from that of normal lymph nodes, and the average ADC value of NPC and metastatic lymph nodes was lower than the average ADC value of normal lymph nodes. The sensitivity and specificity of differentiating nasopharyngeal carcinoma from normal lymph nodes were 94.6 and 72.5 respectively when the threshold value of BX 1000s / mm2ADC was 0.844 脳 10~(-3)mm~2/s, and when the threshold value of ADC was 0.840 脳 10~(-3)mm~2/s, the sensitivity and specificity of differentiating metastatic lymph nodes from normal lymph nodes were 97.3and 75.75 脳 10~(-3)mm~2/s respectively. Conclusion Diffusion-weighted Mr imaging and ADC measurement are valuable in the diagnosis of nasopharyngeal carcinoma and its metastatic lymph nodes.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R445.2;R739.63

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