奥美拉唑治疗反流性咽喉炎的效果

发布时间：2018-05-31 20:23

本文选题：质子泵抑制剂 + 反流性咽喉疾病　；参考：《广东医学》2014年24期

【摘要】：目的观察不同剂量奥美拉唑治疗反流性咽喉炎的临床效果。方法选择确诊反流性咽喉炎患者120例,分为A、B、C 3组,均使用奥美拉唑治疗,剂量分别为20 mg,2次/d;40 mg,2次/d;40 mg,1次/d;每天2次用药在早餐前及晚餐前半小时服药,每天1次用药根据患者酸反流以直立或平卧位为主分别在早餐前或睡前半小时服药,直立平卧反流均出现者则在早餐前半小时服药。共治疗3个月。在治疗后的1、2、3个月,对各组进行症状和体征评分。3个月治疗结束时再次进行食管咽喉双通道p H监测检查,比较各组咽喉部位治疗前后卧位和立位合计反流时间百分比、最长反流持续时间。结果各组症状及体征积分在治疗1个月时已在下降,与治疗前比较,差异有统计学意义(P0.05);治疗3个月时,各组症状及体征及合计反流时间百分比、最长反流持续时间与治疗前比较,差异有统计学意义(P0.01);而B、C组下降更为明显,与A组比较,与治疗前比较,差异有统计学意义(P0.05,P0.01);且B组与C组比较,差异有统计学意义(P0.05)。且合计反流时间百分比立位均比卧位更大,最长反流持续时间立位均比卧位更长。结论反流性咽喉炎的特点以立位反流为主。奥美拉唑治疗反流性咽喉疾病有效,治疗效果以剂量40 mg,2次/d为佳;其次为40 mg,1次/d;再者为20 mg,2次/d。
[Abstract]:Objective to observe the clinical effect of different doses of omeprazole in the treatment of reflux pharyngitis. Methods 120 patients with reflux pharyngitis were selected and divided into three groups: group C: omeprazole (20 mg / d), 40 mg / d 40 mg / d / d, twice a day before breakfast and half an hour before dinner. According to the acid reflux in the upright or supine position, the patients took medicine once a day before breakfast or half an hour before bedtime, while those who had reflux in the upright supine position took medicine half an hour before breakfast. The treatment lasted for 3 months. The symptoms and signs of each group were scored at 2 and 3 months after treatment. After 3 months of treatment, the esophageal laryngopharynx double channel pH monitoring was performed again, and the percentage of total reflux time between the supine position and the standing position before and after treatment was compared in each group. Maximum reflux duration. Results the scores of symptoms and signs in each group were decreased at 1 month after treatment, the difference was statistically significant compared with that before treatment (P 0.05), and at 3 months after treatment, the symptoms and signs of each group and the percentage of total reflux time were increased. The longest duration of reflux was significantly different from that before treatment (P 0.01), while that of group B C was more obvious than that of group A, and the difference was statistically significant compared with group A and group C, and the difference between group B and group C was statistically significant (P 0.05). The percentage of total reflux time was larger in standing position than in lying position, and the longest reflux duration was longer in standing position than in lying position. Conclusion the characteristics of reflux pharyngitis are mainly orthostatic reflux. Omeprazole was effective in the treatment of reflux laryngopharynx disease with the best dose of 40 mg / d, followed by 40 mg / d / d and 20 mg / d / d.
【作者单位】：广东省佛山市中医院耳鼻咽喉科;
【基金】：广东省佛山市医学类科技攻关项目(编号:201108080)
【分类号】：R766.5

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