激光联合曲安奈德治疗糖尿病性黄斑水肿的疗效评价

发布时间：2018-06-03 00:24

本文选题：光学相干断层成像 + 激光光凝术　；参考：《新疆医科大学》2014年硕士论文

【摘要】：目的：通过光学相干断层成像(Optical Coherence Tomography,OCT)评价眼底全视网膜激光光凝术(Panretinal Photocoagulation,PRP)联合玻璃体腔内注射曲安奈德(Triamcinolone Acetonide,TA)治疗糖尿病性黄斑水肿(Diabetic Macular Edema,DME)的疗效。方法：对新疆医科大学第五附属医院2012年3月-2013年10月采用眼底视网膜激光光凝术联合玻璃体腔内注射曲安奈德治疗糖尿病性黄斑水肿的56例病例进行回顾性分析。结果：(1)视力：术后1周、1个月、3个月、6个月的视力与用药前相比均有统计学意义(P0.05)。(2)眼压：术后1周、1月、3月、6月与术前比较均有统计学意义(0.05)。其中术后1周、1月、3月眼压升高明显,6月时开始下降。(3)黄斑中心凹视网膜厚度：治疗后较治疗前明显降低,术后1周、1月、3月、6月之间差异具有统计学意义(P0.05),其中第6月时开始缓慢上升,较治疗前仍有显著差异。(4)黄斑部总体积：较术前相比,患者术后黄斑区总体积减小,术后1周、1月、3月、6月较术前均具有统计学意义(P0.05)。(5)黄斑部平均视网膜厚度：治疗后较术前显著降低,术前与术后1周、1月、3月、6月之间差异具有统计学意义(P0.05)。(6)最佳矫正视力(BCVA)与黄斑中心凹视网膜厚度、黄斑部容积及黄斑区平均视网膜厚度的关系：BCVA分别与黄斑中心凹视网膜厚度、黄斑部总体积、黄斑部平均视网膜厚度具有负相关性。结论：联合治疗DME的治疗方法在短期内可以很好的减轻黄斑水肿,减少黄斑中心凹视网膜厚度、减少黄斑部总体积及黄斑部平均视网膜厚度,从而可以提高视力。
[Abstract]:Objective: to evaluate the efficacy of panretinal photocoagulation combined with intravitreal injection of triamcinolone acetonide (TIA) in the treatment of diabetic macular edema (DM) by optical coherence tomography (Oct). Methods: 56 cases of diabetic macular edema treated by retinal laser photocoagulation combined with intravitreal injection of triamcinolone acetonide from March 2012 to October 2013 in the Fifth affiliated Hospital of Xinjiang Medical University were retrospectively analyzed. Results the visual acuity of 1 week, 1 month, 3 months and 6 months after operation was significantly higher than that before treatment (P 0.05). IOP: 1 week, 1 month, 3 months, 6 months after operation, there was significant difference in IOP between 1 week, 1 month, 3 months, 6 months and preoperation. The intraocular pressure increased significantly at 1 week, 1 month and 3 months postoperatively, and began to decrease at 6 months.) Retinal thickness of central fovea of macula: after treatment, it was significantly lower than that before treatment. The difference was statistically significant between 1 week, 1 month, 3 months and 6 months after the operation, in which the volume of macular area began to rise slowly at the 6th month, and was significantly different from that before treatment. 1 week, 1 month, 3 months and 6 months postoperatively, there were significant differences in the mean retinal thickness of macular region between before and after treatment (P 0.05, P 0.05, P < 0.05). After treatment, the mean retinal thickness was significantly lower than that before treatment. The difference between preoperative and postoperative 1 week, 1 month, 3 months and 6 months was statistically significant (P 0.05) BCVA) and macular central foveal retinal thickness. The relationship between macular volume and mean retinal thickness of macular area was negatively correlated with macular central foveal retinal thickness, total macular volume and mean macular retinal thickness, respectively. Conclusion: the combined treatment of DME can reduce macular edema, macular central fovea retinal thickness, macular total volume and mean macular retinal thickness in a short period of time, so as to improve visual acuity.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R774.1;R587.2

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