湿性年龄相关性黄斑变性眼中外层视网膜管状结构的OCT特征及其临床意义

发布时间：2018-06-04 11:00

本文选题：年龄相关性黄斑变性 + 外层视网膜管状结构　；参考：《眼科新进展》2014年10期

【摘要】：目的观察湿性年龄相关性黄斑变性(age-related macular degeneration,AMD)患者的黄斑部外层视网膜管状结构(outer retinal tubulation,ORT)的OCT特征并分析其临床意义。方法回顾性分析经临床确诊的390例(478眼)湿性AMD患者的黄斑部OCT图像,对ORT的发生率、形态、大小、数量、位置及经抗血管内皮生长因子治疗后的形态变化进行分析总结。结果 478眼中有38眼黄斑部存在ORT,ORT发生率为7.95%;ORT主要存在于外层视网膜,表现为圆形或椭圆形高反射环,其内呈低反射或点状高反射;ORT的长度为73~3230μm,高度为73~183μm,每张OCT图像可见1~4个ORT。38眼中15眼曾接受玻璃体内注射抗血管内皮生长因子药物治疗,治疗后2~4个月黄斑部视网膜水肿减轻或消失,大多数患者ORT大小、位置无明显变化,仅1眼ORT内高反射物质较治疗前减少。结论部分湿性AMD患者黄斑部可见ORT,这些结构不同于视网膜囊样水肿,抗新生血管药物治疗后结构变化不明显或无变化。
[Abstract]:Objective to observe the OCT features and clinical significance of outer retinal tubuloid structure (ORT) of outer retina of macular region in patients with age-related macular degenerationin wet age-related macular degeneration. Methods the macular OCT images of 390 cases (478 eyes) with AMD were analyzed retrospectively. The incidence, shape, size, quantity, location and morphological changes of ORT after treatment with antivascular endothelial growth factor were analyzed and summarized. Results in 478 eyes, the incidence of ORT in macular region was 7.95. ORT was mainly present in the outer retina, with the appearance of circular or elliptical high reflex ring. The length and height of low reflex or dot high reflex ORT were 73 ~ 3230 渭 m and 73 ~ 183 渭 m respectively. 15 eyes of 1 ~ 4 ORT.38 eyes were treated with intravitreous injection of antivascular endothelial growth factor (VEGF). The macular retinal edema was alleviated or disappeared 2 ~ 4 months after treatment. The size and location of ORT in most of the patients did not change obviously. Only one eye had less hyperreflex substance in ORT than before treatment. Conclusion ORT was found in macular region of partial wet AMD patients. These structures were different from retinal sac edema, and the changes of antiangiogenic drugs were not obvious or no change.
【作者单位】：山东省医学科学院山东省眼科研究所青岛眼科医院;
【基金】：山东省医药卫生科技发展计划保健项目(编号:2013BJYB27)~~
【分类号】：R774.5

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