小儿喉乳头状瘤临床特征与HPV感染分析

发布时间：2018-06-07 13:59

  本文选题：小儿喉乳头状瘤 + 发病年龄　； 参考：《广西医科大学》2010年硕士论文

【摘要】： 目的：回顾性分析小儿喉乳头状瘤的临床特征,探索可能影响其临床行为的因素；了解喉乳头状瘤患儿的HPV感染情况及其与临床特征的关系。 方法：收集广西医科大学第一附属医院耳鼻咽喉头颈外科1989.1.1-2009.10.31收治的112例小儿喉乳头状瘤患者的病历资料,包括性别、发病年龄、起病症状、确诊时间、入院主诉、手术方式、病灶部位、是否行气管切开、HPV检测结果等,记录患者手术次数、手术间隔时间、术后辅助治疗等情况。分析患儿性别、HPV感染、气管切开、气管内肿瘤、发病年龄、手术次数、手术频率之间的关系。 结果：共收集112例患者资料,分组统计发现男性患儿组和女性患儿组的HPV感染率、气管切开率、气管内肿瘤发生率、发病年龄及手术频率的差异无显著意义。HPV阳性组和HPV阴性组的气管切开率、气管内肿瘤发生率无统计学差异,HPV阳性组的发病年龄小于HPV阴性组(p=0.05),HPV阳性组的手术频率高于HPV阴性组(p=0.000)。发病年龄≤2岁组的气管切开率、气管内肿瘤发生率高于发病年龄2岁组p=0.039,0.004),患儿手术频率与其发病年龄无明显关系。气管切开组的手术次数高于未气管切开组(p=0.000),但两者气管内肿瘤发生率的差异无显著性。气管内有肿瘤组的手术次数高于气管内无肿瘤组(p=0.000)。患儿的HPV感染率为63.2％。 结论：1.发病年龄≤2岁的喉乳头状瘤患儿有更高的气管切开率和气管内乳头状瘤发生率。2.气管切开与发生气管内乳头状瘤无明显关系。3.HPV感染的患儿发病年龄较小,手术频率较高。
[Abstract]:Objective: to retrospectively analyze the clinical features of laryngeal papilloma in children, explore the factors that may affect its clinical behavior, and understand the infection of HPV in children with laryngeal papilloma and its relationship with clinical features. Methods: the medical records of 112 pediatric patients with laryngeal papilloma admitted to the Department of Otorhinolaryngology and head and neck surgery in the first affiliated Hospital of Guangxi Medical University were collected, including sex, age of onset, onset symptoms, time of diagnosis, admission to hospital and operation methods. The location of the lesion, whether the tracheotomy or HPV test results, recorded the number of operations, surgical interval, postoperative adjuvant treatment and so on. The relationship among sex HPV infection, tracheotomy, intratracheal tumor, age of onset, times of operation and frequency of operation were analyzed. Results: the data of 112 patients were collected. The HPV infection rate, tracheotomy rate and intratracheal tumor rate were found in male and female groups. There was no significant difference in age of onset and frequency of operation. Tracheotomy rate in HPV-positive group and HPV negative group was not significant. There was no significant difference in the incidence of intratracheal neoplasms. The age of onset in HPV-positive group was lower than that in HPV negative group. The frequency of operation in HPV-positive group was higher than that in HPV negative group. The rate of tracheotomy was higher in the age 鈮，

本文编号：1991418