白细胞介素-35在鼻咽癌患者组织和外周血中的表达及意义

发布时间：2018-06-12 12:16

本文选题：鼻咽癌 + 白细胞介素-　；参考：《广东医学》2014年22期

【摘要】：目的探讨鼻咽癌患者组织和外周血白细胞介素-35(IL-35)的表达及意义。方法收集鼻咽癌患者50例,其中21例为角化型鳞状细胞癌,29例为非角化型鳞状细胞癌;发生颈部淋巴结转移者30例,未发生颈部淋巴结转移者20例;T1期10例、T2期16例、T3期19例和T4期5例。ELISA法检测组织和外周血IL-35含量。结果鼻咽癌组织中IL-35含量显著高于癌旁黏膜组织(t=2.415,P=0.018 8)和鼻咽黏膜慢性炎组织(t=2.368,P=0.021 1)。T3~T4期组织IL-35含量显著高于T1~T2期(t=2.139,P=0.037 7);非角化型鳞癌组织IL-35含量显著高于角化型鳞癌(t=2.550,P=0.014 1);有颈部淋巴结转移癌组织IL-35含量显著高于无颈部淋巴结转移癌(t=3.147,P=0.002 9)。鼻咽癌患者外周血中IL-35含量显著高于健康志愿者(t=2.776,P=0.007 3)和鼻咽黏膜慢性炎患者(t=2.122,P=0.038 4)。T3~T4期患者外周血IL-35含量显著高于T1~T2期(t=2.427,P=0.019 7);非角化型鳞癌患者外周血IL-35含量显著高于角化型鳞癌患者(t=2.109,P=0.041 1);有颈部淋巴结转移患者外周血IL-35含量显著高于无颈部淋巴结转移癌患者(t=3.469,P=0.001 2)。鼻咽癌患者组织与外周血之间IL-35含量呈正相关(r=0.405,P=0.003 5)。结论 IL-35可能在鼻咽癌的发生、发展中发挥重要的作用。
[Abstract]:Objective to investigate the expression and significance of interleukin-35 (IL-35) in patients with nasopharyngeal carcinoma (NPC). Methods A total of 50 cases of nasopharyngeal carcinoma (NPC), including 21 cases of keratinized squamous cell carcinoma (KSCC), 29 cases of non-keratinized squamous cell carcinoma (NSCC) and 30 cases of cervical lymph node metastasis, were collected. The levels of IL-35 in tissues and peripheral blood were detected by Elisa in 20 cases with no cervical lymph node metastasis, 10 cases with stage T 1 and 16 cases with stage T 3 and 5 cases with stage T 4. Results the content of IL-35 in nasopharyngeal carcinoma tissues was significantly higher than that in adjacent mucosa tissues (2.415P 0.018) and chronic nasopharyngeal mucosal inflammation tissue (2.368). The level of IL-35 in nasopharyngeal carcinoma tissue was significantly higher than that in T _ 1 / T _ 2 stage (2.139P 0.037 7) and in non-keratinized squamous cell carcinoma tissues (T2.550P0.014), and the level of IL-35 in nasopharyngeal carcinoma was significantly higher than that in non-keratinized squamous cell carcinoma (T2.550P0.014), and the level of IL-35 in nasopharyngeal carcinoma was significantly higher than that in non-keratinized squamous cell carcinoma (T2.550P0.014). The level of IL-35 in metastatic cervical lymph nodes was significantly higher than that in patients without cervical lymph node metastasis. The level of IL-35 in peripheral blood of patients with nasopharyngeal carcinoma was significantly higher than that of healthy volunteers (2.776P0. 007.3) and patients with chronic nasopharyngeal mucositis. The level of IL-35 in peripheral blood of patients with chronic nasopharyngeal mucositis was significantly higher than that of patients with stage T1T 2. 427P0. 019 7, and the level of IL-35 in patients with non keratinized squamous cell carcinoma was significantly higher than that in patients with non keratinized squamous cell carcinoma. The level of IL-35 in peripheral blood in patients with cervical lymph node metastasis was significantly higher than that in patients without cervical lymph node metastasis. There was a positive correlation between the level of IL-35 in nasopharyngeal carcinoma tissue and peripheral blood. Conclusion IL-35 may play an important role in the pathogenesis and development of nasopharyngeal carcinoma.
【作者单位】：广东省佛山市南海区人民医院耳鼻咽喉科;广东医学院广东省医学分子诊断重点实验室;广东医学院附属医院耳鼻咽喉科;
【基金】：广东省佛山市医学类科技攻关项目(编号:201308188)
【分类号】：R739.63

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