影响喉癌自然生存率的多因素分析

发布时间：2018-06-13 05:34

  本文选题：喉肿瘤 + 因素分析　； 参考：《重庆医科大学》2010年硕士论文

【摘要】： 目的:探讨喉癌的自然生存率及其影响因素。 方法:回顾性分析2000年1月1日至2007年12月31日188例未行喉切除术及放化疗治疗的喉癌患者的临床资料,包括年龄、吸烟史、肿瘤家族史、结核病史、肿瘤生长部位、病理学分级、T分期、N分期、临床分期以及有无气管切开术史。应用Kaplan-Meier乘极限法计算生存率,单因素分析组间比较采用Log-rank检验,多因素分析采用Cox比例风险模型。 结果:总的中位生存时间为14±1.47月,1年、2年、5年生存率分别为54.7%、26.6%、11.0%;确诊超过5年的病例(除失访者外)尚无一例生存超过5年。0/Ⅰ/Ⅱ期中位生存时间为33±5.72月,1年、2年生存率分别为75.1%、57.9%;Ⅲ/Ⅳ期中位生存时间为10±1.31月,1年、2年生存率分别为43.2%、11.4%。单因素分析显示肿瘤生长部位、病理学分级、T分期、N分期、临床分期对生存率的影响有统计学意义(P0.05),而是否行气管切开术无统计学意义。多因素分析显示病理学分级、临床分期对生存率的影响有统计学意义(P0.05)。 结论:喉癌自然病程发展较快,在未针对肿瘤本身治疗的情况下,即便行姑息性手术如气管切开术亦不能提高生存率;影响喉癌自然生存率的因素为肿瘤生长部位、病理学分级、T分期、N分期、临床分期,其中独立危险因素为病理学分级和临床分期。
[Abstract]:Objective: to investigate the natural survival rate of laryngeal carcinoma and its influencing factors. Methods: the clinical data of 188 patients with laryngeal cancer without laryngectomy or radiotherapy and chemotherapy from January 1, 2000 to December 31, 2007 were retrospectively analyzed, including age, history of smoking, family history of cancer, history of tuberculosis, location of tumor growth. Pathological grading T staging N staging, clinical staging and history of tracheotomy. The survival rate was calculated by Kaplan-Meier multiplication limit method. The comparison between univariate analysis groups was performed with Log-rank test and multivariate analysis with Cox proportional risk model. Results: the overall median survival time was 14 卤1.47 months, 1 year, 2 years and 5 years survival rate was 54.7 and 26.60.Not one case (except those who lost the interview) had survived more than 5 years. The median survival time was 33 卤5.72 months and 2 / 1 respectively. The annual survival rate was 75.1% and 57.9%, and the median survival time of stage 鈪，

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