异种脱细胞真皮基质联合自体骨粉在开放式鼓室成形术中的应用

发布时间：2018-06-18 03:15

本文选题：异种脱细胞真皮基质 + 鼓室成形术　；参考：《临床耳鼻咽喉头颈外科杂志》2014年19期

【摘要】：目的:探讨异种脱细胞真皮基质联合自体骨粉在开放式鼓室成形术中的临床价值。方法:将50例(52耳)行开放式鼓室成形术的中耳胆脂瘤患者分为2组。研究组28例(30耳)患者行开放式鼓室成形术+异种脱细胞真皮基质联合自体骨粉外耳道重建术;对照组22例(22耳)行常规开放式鼓室成形术。术后随访12~18个月,观察2组患者术后听力结果、干耳率及并发症情况。结果:研究组干耳率90.0%(27/30),明显高于对照组72.7%(16/22),差异有统计学意义(P0.05)。研究组重建后的外耳道结构接近正常,无狭窄情况发生,中耳腔接近正常,全部患者均无胆脂瘤复发。结论:应用脱细胞真皮基质联合自体骨粉能够起到早期覆盖创面,促进创面愈合,缩小外耳道,减少肉芽及瘢痕生成的作用,术后干耳率高,听力恢复满意,是一种值得推广的修复方法。
[Abstract]:Objective: to investigate the clinical value of xenogeneic acellular dermal matrix combined with autogenous bone powder in open tympanoplasty. Methods: 50 patients with middle ear cholesteatoma underwent open tympanoplasty were divided into two groups. In the study group, 28 cases (30 ears) underwent open tympanoplasty, and 22 cases (22 ears) were treated with conventional open tympanoplasty. All patients were followed up for 12 ~ 18 months. The hearing, dry ear rate and complications were observed in the two groups. Results: the dry ear rate of the study group was 90.0% and 27 / 30%, which was significantly higher than that of the control group (72.7%, 16 / 22), and the difference was statistically significant (P 0.05). After the reconstruction of the study group, the external auditory canal structure was nearly normal, no stenosis occurred, the middle ear cavity was close to normal, and no cholesteatoma recurred in all the patients. Conclusion: the application of acellular dermal matrix combined with autogenous bone powder can cover wounds early, promote wound healing, reduce external auditory canal, and reduce granulation and scar formation. The dry ear rate is high and hearing recovery is satisfactory. It is a method worth popularizing.
【作者单位】：南方医科大学南方医院耳鼻咽喉-头颈外科;东莞市第五人民医院耳鼻咽喉-头颈外科;中国人民解放军总医院耳鼻咽喉-头颈外科;
【基金】：广东省自然科学基金(No:10151051501000068) 东莞市卫生科技基金项目(No:201210515025055)
【分类号】：R764.9

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