七叶皂苷钠治疗糖尿病黄斑水肿的疗效观察

发布时间：2018-06-20 07:26

本文选题：七叶皂苷钠 + 糖尿病　；参考：《眼科新进展》2014年12期

【摘要】：目的探讨七叶皂苷钠治疗糖尿病黄斑水肿的疗效及安全性,为临床治疗提供一定的参考依据。方法通过光学相干断层扫描检测98例糖尿病黄斑水肿患者服用七叶皂苷钠片治疗前后的黄斑水肿厚度,同时检测不同治疗时间双眼视力,进一步分析其治疗糖尿病黄斑水肿的效果,治疗同时监测患者服药期间不良反应发生情况,评价其安全性。结果 98例患者双眼黄斑水肿厚度与给药前相比,给药结束及停药4周时均明显变薄,差异有显著统计学意义(P0.01),且停药4周时黄斑水肿变薄更明显。其中右眼由给药前(399.7±83.3)μm变薄至停药4周时(319.8±89.4)μm,左眼则由(408.5±87.0)μm变薄至(314.7±86.2)μm。患者裸眼视力及最佳矫正视力均随用药时间逐渐提高,且在给药8~12周时提高较明显,差异有统计学意义(P0.05),其中双眼最佳矫正视力均由给药前的0.4±0.1明显提高至停药4周时的0.7±0.2。服药期间共有16例(16.3%)患者发生胃部不适、恶心等不良反应,2例因反应较重而退出研究,2例(2%)患者症状持续存在,其余均痊愈或留有轻微后遗症。结论七叶皂苷钠片治疗糖尿病黄斑水肿疗效好且安全性高,值得在临床推广应用。
[Abstract]:Objective to investigate the efficacy and safety of sodium aescinate in the treatment of diabetic macular edema. Methods the macular edema thickness of 98 patients with diabetic macular edema was measured by optical coherence tomography before and after treatment with sodium aescinate tablets. Further analysis of the effect of the treatment of diabetic macular edema, monitoring of adverse reactions during the treatment and evaluation of its safety. Results the thickness of macular edema in the eyes of 98 patients was significantly thinner at the end of administration and at 4 weeks after withdrawal than before administration, and the difference was statistically significant (P 0.01), and the thickness of macular edema was more obvious at 4 weeks after withdrawal. The right eye was thinned from 399.7 卤83.3) 渭 m before administration to 319.8 卤89.4 渭 m at the end of 4 weeks, and the left eye was thinned from 408.5 卤87.0) 渭 m to 314.7 卤86.2 渭 m. The uncorrected visual acuity and the best corrected visual acuity of the patients were improved gradually with the time of medication, and the difference was significant at the 12th week of administration (P 0.05). The best corrected visual acuity of both eyes increased from 0.4 卤0.1 before administration to 0.7 卤0.2 at the end of 4 weeks. There were 16 patients with stomach discomfort, 2 patients with nausea and 2 patients who quit the study because of serious reaction. The rest were cured or had slight sequelae. Conclusion Sodium aescinate tablets are effective and safe in the treatment of diabetic macular edema.
【作者单位】：解放军总医院眼科;
【分类号】：R587.2;R774.5

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