亮蓝与吲哚菁绿辅助内界膜染色治疗特发性黄斑裂孔效果对比

发布时间：2018-06-25 03:32

本文选题：特发性黄斑裂孔 + 内界膜染色　；参考：《郑州大学》2011年硕士论文

【摘要】：目的比较亮蓝(brilliant blue G, BBG)与吲哚菁绿(indocyanine green, ICG)辅助内界膜染色治疗特发性黄斑裂孔(idiopathic macular hole, IMH)的效果。材料和方法回顾分析2009年1月至2010年10月在我小组因特发性黄斑裂孔而接受玻璃体切除(par plana vitrectomy,PPV)联合内界膜(internal limiting membrane, ILM)剥离治疗的患者。根据术前检查,排除Ⅰ、Ⅱ期和术后因白内障加重需行白内障手术的黄斑裂孔,共有Ⅲ和Ⅳ黄斑裂孔44例(46只眼)。按术中内界膜染色时使用的染色剂分为2组：20眼使用0.25%BBG染色(BBG组)；26眼使用0.25%ICG染色(ICG组)。比较两组术中染色效果、剥膜率,术后两组患者的裂孔闭合率、最佳矫正视力(best corrected visual acuity, BCVA)(术后3月时)等改变。结果两组患者的年龄、术前最佳矫正视力无统计学意义(p0.05)。术中BBG或ICG使所有患眼ILM染色,均有效增加了ILM的可见度,染色率为100%。BBG将ILM染成淡蓝色,ICG将ILM染成淡绿色,但后者染色效果更清晰。两组均顺利剥除ILM,剥除率为100%。两组中除ICG组有1眼术后黄斑裂孔未闭合外,其余眼黄斑裂孔完全闭合。BBG组术后BCVA提高程度为0.46±0.08；ICG组术后BCVA提高程度为0.45±0.05,同术前相比视力明显提高,差异均有统计学意义(p0.05)。分析两组间的裂孔闭合率(p=0.926)和BCVA提高程度p=0.098)差异均无统计学意义(p0.05)。两组病例均未发生严重手术并发症。结论在特发性黄斑孔患者,0.25%BBG与0.25%ICG均使所有的ILM染色并剥离,染色率、剥膜率均为100%；两组术后裂孔闭合率、BCVA提高程度无统计学差异。
[Abstract]:objective
The effect of brilliant blue G (BBG) and indocyanine green (indocyanine green, ICG) on the treatment of idiopathic macular hole (idiopathic macular hole, IMH) was compared with indocyanine green (ICG).
Materials and methods
A retrospective analysis was made of patients with par plana vitrectomy (PPV) combined with internal boundary membrane (internal limiting membrane, ILM) dissection in our group from January 2009 to October 2010. According to the preoperative examination, the macular holes in cataract surgery were eliminated in stage I, stage II and after cataract surgery. 44 cases (46 eyes) of macular hole (46 eyes) were divided into 2 groups according to intraoperative membrane staining: 20 eyes were stained with 0.25%BBG (group BBG); 26 eyes were stained with 0.25%ICG (group ICG). The staining effect, the stripping rate, the split hole closure rate of two groups of patients and the best corrected visual acuity (best corrected visual acuity, BCVA) were compared in the 26 eyes (group ICG). The change in March).
Result
The best corrected visual acuity before operation was not statistically significant in the two groups (P0.05). BBG or ICG during the operation made all eyes ILM dyed, which increased the visibility of ILM effectively. The staining rate was 100%.BBG, ILM was dyed light blue, ICG turned ILM into light green, but the latter dyeing effect was clearer. The two groups were all smoothly stripped of ILM and the stripping rate was I except I in 100%. two groups. In group CG, after 1 eyes, the macular hole was not closed, the other eye macular hole completely closed in group.BBG was 0.46 + 0.08 after operation, and the degree of BCVA improvement in group ICG was 0.45 + 0.05 after operation, and the visual acuity was significantly higher than that before operation. The difference was statistically significant (P0.05). The fracture closure rate (p=0.926) and BCVA improvement degree p=0.09 between the two groups were analyzed. 8) the difference was not statistically significant (P0.05). No serious operative complications occurred in the two groups.
conclusion
In the patients with idiopathic macular holes, both 0.25%BBG and 0.25%ICG were stained and stripped of all ILM, the rate of dyeing and the stripping rate were 100%, and there was no statistical difference between the two groups.
【学位授予单位】：郑州大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R779.6

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