人眼高阶波前像差年龄相关性研究

发布时间：2018-06-29 04:04

本文选题：人眼 + 总高阶像差　；参考：《山西医科大学》2014年硕士论文

【摘要】：目的：本文旨在研究正常人眼高阶波前像差的特点及其年龄相关性分析,为各年龄段波前像差引导的准分子屈光手术和个体化的人工晶体设计提供重要的依据,同时有助于我们确定各年龄段人眼高阶像差的正常范围,为临床工作服务。方法：随机收集2013年1月至2013年11月在某某市某某医院拟行屈光性手术及志愿者共180只眼(男女各90只眼),年龄范围是18-68,按10年为一个年龄段进行分组,共5组,每组36只眼(男女各18只眼),通过对受试眼进行波前像差(Wave Scan客观波前像差测量仪,美国VISX公司)检查,得出各个年龄段的高阶像差,包括总高阶像差、球差、慧差、三叶草差,运用SPSS13.0统计分析软件对所得的数据与年龄进行相关性分析,了解正常人眼高阶像差与年龄之间的相关性,同时用非参数独立样本检验分析男女各高阶像差有无差异。结果： 1.人眼的总高阶像差均方根数值平均为(0.371±0.153)μm,范围：(0.097～1.007)μm,人眼的总高阶像差随年龄的增长而增加(spearman相关系数分别为r=0.450,p=0.0000.05),即人眼的总高阶像差与年龄呈正相关性,有显著统计学意义。 2.总球差均方根数值平均为(0.173±0.129)μm,范围：(0.004～0.647)u m,人眼的总球差随年龄的增长而增加(spearman相关系数分别为r=0.391,p=0.0000.05),即人眼的总球差与年龄呈正相关性,有显著统计学意义。 3.总慧差均方根数值平均为(0.200±0.121)μm,范围：(0.018～0.607)μ m,人眼的总高阶像差随年龄的增长而增加(spearman相关系数分别为(r=0.244,p=0.0010.05),即人眼的总慧差与年龄呈正相关性,有显著统计学意义。 4.总三叶草差均方根数值平均为(0.188±0.111)μ m,范围：(0.001～0.868)μ m,人眼的总高阶像差随年龄的增长而增加(spearman相关系数分别为r=0.255,p=0.0020.05),即人眼的总三叶草差与年龄呈正相关性,有显著统计学意义。 5.通过分别对男组与女组各高阶像差进行非参数检验,得出总高阶像差男女组比较P=0.2220.05；总球差男女组比较P=0.7420.05；总慧差男女组比较P=0.2890.05；总三叶草差男女组比较P=0.2800.05；说明各高阶像差男组与女组均无差异统计学意义。结论：正常人眼的总高阶像差、球差、慧差、三叶草差均随着年龄的增加而增大,即正常人眼的总高阶像差、球差、慧差、三叶草差均与年龄呈正相关性。而且分别通过对男女组的高阶像差进行比较,说明高阶像差男组与女组无差异统计学意义。
[Abstract]:Objective: to study the characteristics of high order wavefront aberration in normal eyes and its age correlation, and to provide an important basis for wavefront aberration guided excimer refractive surgery and individualized intraocular lens design. It also helps us to determine the normal range of higher-order aberrations of human eyes of all ages and to serve the clinical work. Methods: from January 2013 to November 2013, 180 eyes (90 eyes of male and 90 eyes of male) were randomly selected for refractive surgery and volunteers in a hospital of a certain city from January 2013 to November 2013. The age range was 18 to 68. The subjects were divided into 5 groups according to 10 years as one age group. In each group, 36 eyes (18 eyes of male and 18 eyes of male and female) were examined with wavefront aberration (Wave scan objective wavefront aberration measuring instrument, VISX Company, USA). The higher order aberrations of each age group, including total high order aberration, spherical aberration, wisdom aberration, were obtained. The correlation between the data and age was analyzed by SPSS 13.0 statistical analysis software, and the correlation between higher order aberration and age of normal human eyes was studied. At the same time, non-parametric independent samples were used to test the difference between male and female higher order aberration. Results: 1. The root mean square (RMS) of total higher-order aberrations in human eyes was (0.371 卤0.153) 渭 m, and the range was (0.097 ~ 1.007) 渭 m. The total high-order aberrations of human eyes increased with age (spearman correlation coefficients were 0.450 p0.0000.05), that is, the total high-order aberrations of human eyes were positively correlated with age. There is significant statistical significance. 2. The mean root mean square (RMS) of total spherical aberration was (0.173 卤0.129) 渭 m, and the range was: (0.004 卤0.647) u m,). The total spherical aberration increased with age (spearman correlation coefficient was 0.391p0.0000.05), that is, the total spherical aberration of human eyes was positively correlated with age, with significant statistical significance. The mean root mean square value of total wisdom difference was (0.200 卤0.121) 渭 m, the range was (0.018 ~ 0.607) 渭 m. The total higher-order aberration of human eyes increased with age (spearman correlation coefficient was (r = 0.244) P 0.0010.05), that is, the total wisdom difference of human eyes was positively correlated with age, with significant statistical significance. The mean root mean square value of total clover difference was (0.188 卤0.111) 渭 m, and the range was (0.001 卤0.868) 渭 m. The total high order aberration of human eyes increased with age (spearman correlation coefficient was 0.255 0. 0020.05), that is, the total clover difference of human eyes was positively correlated with age. Significant statistical significance. 5. By nonparametric tests on the higher order aberrations of male and female groups, the comparison of male and female groups with total high order aberration was obtained, the comparison of male and female groups with total spherical aberration was 0.7420.05, the comparison of male and female group of total maleic aberration with that of male group was 0.2890.05, the comparison of male and female group of total clover difference with male group was 0.2800.05, and that of male and female group of total maleic aberration was 0.2800.05. The results showed that there was no significant difference between the male group and the female group. Conclusion: the total high order aberration, spherical aberration, wisdom aberration and clover aberration of normal eyes are all increased with the increase of age, that is, the total high order aberration, spherical aberration, wisdom aberration and clover difference of normal human eyes are positively correlated with age. By comparing the higher order aberrations of male and female groups, the results showed that there was no statistical difference between the male group and the female group.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R770.4

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