越橘提取物对非增生性糖尿病视网膜病变患者对比敏感度的影响

发布时间：2018-06-29 05:11

本文选题：越橘提取物 + 糖尿病视网膜病变　；参考：《眼科新进展》2014年01期

【摘要】：目的观察越橘提取物(vaccinium myrtillus extracts,VME)治疗轻中度非增生性糖尿病视网膜病变(non-proliferative diabetic retinopathy,NPDR)的疗效及对比敏感度(contrast sensitivity,CS)的变化。方法选择轻中度NPDR患者75例(均选择右眼),随机分为试验组和对照组,试验组42例42眼,对照组33例33眼。试验组予以VME 200 mg,每天3次,口服;对照组予以安慰剂维生素C片,100 mg,每天3次,口服;疗程为8周。于用药前后行最佳矫正视力(BCVA)检查,同时行6 c·d-1和12 c·d-1模式下CS的检测。结果共有69例轻中度NPDR患者(试验组38眼,对照组31眼)完成了8周的临床观察。用药前两组间患者一般情况,性别、年龄、空腹血糖、糖化血红蛋白等指标无明显差异(均为P0.05);用药前试验组和对照组BCVA分别为0.232和0.192,差异无统计学意义(t=0.189,P=0.239);试验组治疗后BCVA值为0.220,较用药前提高0.012,但差异无统计学意义(t=1.273,P=0.211)。试验组患者在用药前中高频模式下(6 c·d-1和12 c·d-1)的平均CS分别为85.656和47.281,与对照组相比,差异均无统计学意义(均为P0.05)。应用VME治疗后,试验组的CS值较治疗前明显增高,分别为89.313和50.941,差异均有统计学意义(均为P0.001);与对照组相比较差异均有统计学意义(t=7.538、11.868,均为P0.001)。结论 VME可改善NPDR患者的CS,对糖尿病视网膜具有保护作用。
[Abstract]:Objective to observe the effect of (vaccinium myrtillus extract in the treatment of non-proliferative diabetic retinopathy (non-proliferative diabetic retinopathy) and the changes of contrast sensitivity (CS). Methods 75 patients with mild and moderate NPDR were randomly divided into two groups: the experimental group (42 eyes, 42 eyes) and the control group (33 cases, 33 eyes). The experimental group was given VME 200 mg three times a day and the control group was given placebo vitamin C 100 mg three times a day for 8 weeks. The best corrected visual acuity (BCVA) was examined before and after medication, and the CS was detected in 6 c d-1 and 12 c d-1 mode. Results A total of 69 mild and moderate NPDR patients (38 eyes in the trial group and 31 eyes in the control group) completed 8 weeks clinical observation. The general condition, sex, age, fasting blood glucose between the two groups before medication, There was no significant difference in BCVA between the test group and the control group (0.232 and 0.192, respectively) (t = 0.189, P < 0.05), and the BCVA value in the test group was 0.220, which was 0.012 higher than that before the treatment, but there was no significant difference between the two groups (t1.273P0. 211). The average CS of the patients in the test group was 85.656 and 47.281 respectively under the mode of middle and high frequency (6 c d-1 and 12 c d-1), which had no significant difference compared with the control group (P0.05). After treatment with VME, the CS value of the experimental group was significantly higher than that of the control group (89.313 and 50.941, respectively), the difference was statistically significant (P0.001), and the difference was statistically significant compared with that of the control group (T7.538868, all P0.001). Conclusion VME can improve the CSS of NPDR patients and protect the retina of diabetic patients.
【作者单位】：中国医科大学附属盛京医院眼科;
【分类号】：R587.1;R774.1

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