θ节律串刺激对视觉空间注意的行为学及事件相关电位研究

发布时间：2018-07-07 21:27

本文选题：视觉空间注意 + 事件相关电位　；参考：《中国康复医学杂志》2014年11期

【摘要】：目的:研究持续性θ节律串刺激(c TBS)对视觉空间注意障碍的作用机制。方法:将30例正常受试者随机分为实验组(刺激组)和对照组(假刺激组),两组经过TBS刺激后进行事件相关电位(ERP)实验,实验范式为"提示—靶",包括范围提示和汉字提示,范围提示为"大"圈和"小"圈,汉字提示为"大"字和"小"字。TBS刺激参数频率为30Hz,刺激强度为刺激器输出的50%,刺激部位为受试者右侧大脑的顶叶后部(P4),刺激脉冲801串,刺激间隔100ms。结果:实验组和对照组在汉字提示和范围提示时,反应时表现出提示等级效应(P0.05)。实验组与对照组比较,在汉字提示下P1、P2波幅明显低于对照组(P0.05),在范围提示下PO4部位的P1、N1、N2波幅明显低于对照组(P0.05)。实验组汉字提示与范围提示比较,范围提示时P1、P2、N2波幅更大(P0.05);对照组汉字提示与范围提示比较,范围提示时P1、N1、P2波幅更大(P0.05)。结论:对右侧顶后叶皮质(PPC)进行抑制性c TBS刺激,能够影响大脑皮质神经元兴奋性活动,尤其会影响对左侧靶目标的识别及加工。
[Abstract]:Aim: to study the mechanism of sustained 胃 rhythm series stimulation (c TBS) on visual spatial attention disorder. Methods: thirty normal subjects were randomly divided into two groups: experimental group (stimulus group) and control group (sham stimulation group). After TBS stimulation, event-related potentials (ERP) were tested in two groups. The experimental paradigm was "cue-target", including range hint and Chinese character hint. The range was indicated as "big" circle and "small" circle, and Chinese characters as "big" word and "small" word. TBS stimulation parameter frequency was 30 Hz, stimulus intensity was 50 parts of stimulator output, stimulation site was right posterior parietal lobe (P4), stimulation pulse was 801 string. The interval of stimulation was 100 Ms. Results: the experimental group and the control group showed cues grade effect in Chinese character cues and range cues (P0.05). Compared with the control group, the amplitude of P _ (1) P _ (2) was significantly lower in the experimental group than that in the control group (P0.05), and the amplitude of P _ (1) P _ (1) N _ (1) N _ (2) was significantly lower than that in the control group (P < 0.05). In the experimental group, compared with the range hint, the amplitude of P1P _ 2N _ 2 N _ 2 was larger when the range prompted (P0.05); in the control group, compared with the range hint, the amplitude of P _ (1) N _ (1) P _ (2) was larger when the range prompted (P0.05). Conclusion: the inhibitory c TBS stimulation of the right posterior parietal cortex (PPC) can affect the excitatory activity of neurons in the cerebral cortex, especially the recognition and processing of the left target.
【作者单位】：首都医科大学宣武医院康复医学科;华北电网有限公司北京电力医院神经内科;首都医科大学附属北京同仁医院康复医学科;
【基金】：国家自然科学基金资助项目(30770714,81171024,81371194) 北京市自然科学基金资助项目(7052030) 首都医学发展科研基金(2007-2068) 高等学校博士学科点专项科研基金(20091107110004) 北京市卫生系统高层次卫生技术人才培养计划(2009-3-62)
【分类号】：R77

【参考文献】