葡萄膜炎患者血清胆红素、尿酸及白蛋白浓度分析

发布时间：2018-07-08 16:56

本文选题：葡萄膜炎 + 氧化应激　；参考：《眼科新进展》2014年04期

【摘要】：目的检测葡萄膜炎患者血清胆红素、尿酸及白蛋白水平,探讨血清胆红素、尿酸及白蛋白含量与葡萄膜炎病理机制的可能关系。方法 23例临床确诊的葡萄膜炎患者(葡萄膜炎组)及年龄和性别相匹配的30例健康对照者(对照组)纳入研究。对比分析两组间血清胆红素、尿酸及白蛋白浓度差异;各组间不同性别者血清胆红素、尿酸及白蛋白浓度差异。结果葡萄膜炎组血清总胆红素(10.89±4.25)μmol·L-1、直接胆红素(2.57±1.46)μmol·L-1、间接胆红素(8.32±3.11)μmol·L-1、尿酸(279.93±107.53)μmol·L-1及白蛋白(43.05±3.70)g·L-1均比健康对照组明显降低(均为P0.05)。葡萄膜炎组和健康组男性、女性之间的总胆红素、直接胆红素、间接胆红素、尿酸及白蛋白浓度无明显区别;但男性和女性葡萄膜炎患者血清总胆红素、直接胆红素、间接胆红素均比同性别健康对照组明显降低(均为P0.05);女性葡萄膜炎患者血清白蛋白亦比同性别健康对照组明显降低(P0.05)。男性和女性葡萄膜炎患者血清尿酸比同性别健康对照组降低,男性葡萄膜炎患者血清白蛋白比男性健康对照组降低,但差异均无统计学意义(均为P0.05)。结论葡萄膜炎患者血清胆红素、尿酸及白蛋白浓度降低,患者处于低水平的抗氧化状态。
[Abstract]:Objective to detect the levels of serum bilirubin, uric acid and albumin in patients with uveitis, and to explore the possible relationship between the levels of serum bilirubin, uric acid and albumin and the pathological mechanism of uveitis. Methods 23 clinically diagnosed uveitis patients (uveitis group) and 30 age-sex matched healthy controls (control group) were included in the study. The difference of serum bilirubin, uric acid and albumin between the two groups and the difference of serum bilirubin, uric acid and albumin between the two groups were analyzed. Results Serum total bilirubin (10.89 卤4.25) 渭 mol L-1, direct bilirubin (2.57 卤1.46) 渭 mol L-1, indirect bilirubin (8.32 卤3.11) 渭 mol L-1, uric acid (279.93 卤107.53) 渭 mol L-1 and albumin (43.05 卤3.70) g L-1 in the uveitis group were significantly lower than those in the control group (P0.05). There was no significant difference in serum total bilirubin, direct bilirubin, indirect bilirubin, uric acid and albumin between male and female patients with uveitis, but serum total bilirubin and direct bilirubin in male and female patients with uveitis. Indirect bilirubin was significantly lower than that of the same sex healthy control group (P0.05), and the serum albumin of female uveitis patients was significantly lower than that of the same gender healthy control group (P0.05). The serum uric acid of male and female uveitis patients was lower than that of the same sex healthy control group, and the serum albumin of male uveitis patients was lower than that of male healthy control group, but the difference was not statistically significant (P0.05). Conclusion the serum bilirubin, uric acid and albumin concentrations in the patients with uveitis were decreased, and the patients were in a low state of antioxidation.
【作者单位】：中山大学附属第三医院眼科;
【分类号】：R773

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