中国人群食用蔬菜及水果与鼻咽癌关系Meta分析

发布时间：2018-07-13 20:08

【摘要】：目的系统评价中国人群食用蔬菜及水果与鼻咽癌之间的关系及关联强度,为我国鼻咽癌的防治策略提供依据。方法系统检索CNKI、万方和维普3个中文数据库及PudMed、ScienceDirect和SpringerLink 3个英文数据库2013-03之前发表的鼻咽癌病例对照研究及队列研究。文献检索、选取、信息提取及质量评价(NOS评分)均由2人独立进行。采用基于方差倒数加权的随机效应模型计算合并的OR值及相应95%的置信区间(95%CI)。结果共有11篇病例对照研究纳入最终的分析,包括2篇高质量的研究和9篇中等质量的研究,共涉及来自全国5个省份的鼻咽癌患者4 162例,对照4 588例。在合并所有研究之后发现,食用蔬菜与鼻咽癌发病风险之间存在显著的负相关,OR=0.52,95%CI:0.27~0.77;I2=82.8%,P0.001;N=5;而食用绿色蔬菜与鼻咽癌发病风险的OR=0.59,95%CI:0.36~0.82;I2=89.2%,P0.001;N=7。同时,食用水果与鼻咽癌发病风险的OR=0.63,95%CI:0.56~0.70;I2=0,P=0.506;N=8。基于发表偏倚检验的结果提示,除绿色蔬菜与鼻咽癌发病风险的纳入研究之间存在潜在的发表偏倚外,尚不能认为其他两项Meta分析纳入研究之间存在潜在的发表偏倚。结论在中国,食用蔬菜及水果,尤其是食用蔬菜,均有可能降低鼻咽癌的发病风险,未来应该强调食用蔬菜及水果在对我国鼻咽癌预防中的保护作用。
[Abstract]:Objective to evaluate the relationship between edible vegetables and fruits and nasopharyngeal carcinoma (NPC) in Chinese population and to provide evidence for prevention and treatment of NPC in China. Methods three Chinese databases, CNKI, Wanfang and Weipu, and three English databases, PudMedence ScienceDirect and SpringerLink, were systematically searched for nasopharyngeal carcinoma case-control studies and cohort studies. Literature retrieval, selection, information extraction and quality evaluation (NOS score) were conducted by two individuals independently. The combined OR value and the corresponding 95% confidence interval (95 CI) are calculated by the stochastic effect model based on reciprocal weighting of variance. Results A total of 11 case-control studies were included in the final analysis, including 2 high quality studies and 9 moderate quality studies, involving 4 162 NPC patients from 5 provinces and 4 588 controls. After combining all the studies, a significant negative correlation was found between eating vegetables and the risk of nasopharyngeal carcinoma (NPC). There was a significant negative correlation between eating vegetables and the risk of nasopharyngeal carcinoma (NPC). There was a significant negative correlation between eating vegetables and the risk of nasopharyngeal carcinoma (NPC). There was a significant negative correlation between eating vegetables and the risk of nasopharyngeal carcinoma (NPC), and there was a significant negative correlation between eating vegetables and the risk of nasopharyngeal carcinoma (NPC), and there was a significant negative correlation between eating vegetables and the risk of nasopharyngeal carcinoma (NPC). At the same time, the OR0.63 ~ 95% CI: 0.56 ~ 0.70 ~ (0.70) I ~ (2 +) I ~ (2 +) ~ (0.506) N ~ (8) of fruit and nasopharyngeal carcinoma (NPC) were taken into account. Based on the results of the publication bias test, we can not conclude that there is a potential publication bias between the other two meta-analysis studies except the potential publication bias between green vegetables and the risk of nasopharyngeal carcinoma (NPC). Conclusion in China, edible vegetables and fruits, especially edible vegetables, may reduce the risk of NPC. In the future, we should emphasize the protective effect of edible vegetables and fruits on the prevention of NPC in China.
【作者单位】：中国医学科学院肿瘤医院肿瘤研究所中心实验室;首都医科大学附属北京儿童医院耳鼻咽喉-头颈外科;天津医科大学肿瘤医院肿瘤研究所;首都医科大学附属北京儿童医院儿科研究所;首都医科大学附属北京同仁医院耳鼻咽喉-头颈外科;
【基金】：首都医科大学附属北京儿童医院科研项目(2012ZD01) 国际科技合作与交流专项(2012DFG31620)
【分类号】：R739.63

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