已治愈单眼弱视患者多焦视觉诱发电位的研究

发布时间：2018-07-22 17:01

【摘要】：目的评价已治愈的单眼弱视患者多焦视觉诱发电位(multifocal visual evoked potential, mfVEP)的恢复情况。方法记录32例6～15岁已治愈的单眼弱视(斜视性弱视、屈光参差性弱视或斜视性弱视合并屈光参差性弱视)患者及30例7～17岁正常人多焦视觉诱发电位,分别比较已治愈单眼弱视患者弱视眼、对侧眼及正常人三组之间上、下半视野不同离心度(1环、2环、3环、4环)多焦视觉诱发电位特征峰P波的潜伏期及振幅密度。结果弱视眼上、下半视野1环、2环、3环、4环特征峰P波潜伏期及振幅密度较对侧眼差别均无统计学意义(P0.05)；弱视眼和对侧眼上、下半视野1环、2环、3环、4环的特征峰P波潜伏期均较正常组显著延长,差别有统计学意义(P0.05),而振幅密度较正常对照组差别无统计学意义(P0.05)。结论1.已治愈单眼弱视患者,随着视力恢复至正常水平,弱视眼的上、下半视野四个离心度mfVEP特征峰P波潜伏期和振幅密度可恢复至与对侧眼相当水平。 2.已治愈单眼弱视患者弱视眼和对侧眼的上、下半视野四个离心度mfVEP特征峰P波潜伏期和振幅密度虽然无显著差别,但弱视眼、对侧眼分别与正常人比较时,它们的潜伏期仍较正常人延长,说明已治愈单眼弱视患者弱视眼和对侧眼的传导通路及视皮层仍存在异常。 3.已治愈单眼弱视患者弱视眼和对侧眼的上、下半视野四个离心度mfVEP特征峰P波振幅密度与正常人比较,三组之间的差别无统计学意义,表明已治愈的单眼弱视患者的mfVEP的振幅密度较潜伏期提前恢复至正常人水平。
[Abstract]:Objective to evaluate the recovery of multifocal visual evoked potential (multifocal visual evoked potential, MF VEP) in patients with monocular amblyopia. Methods 32 cases of amblyopia (strabismus amblyopia, anisometropic amblyopia or strabismus amblyopia with anisometropia amblyopia) and 30 normal subjects aged 7 to 17 years were studied. The latency and amplitude density of the characteristic P wave of multifocal visual evoked potential in amblyopic eyes, contralateral eyes and normal subjects were compared. Results in amblyopic eyes, there was no significant difference in P wave latency and amplitude density between the eyes with amblyopia (P 0.05), the amblyopia eyes and the contralateral eyes (P < 0.05), and the P wave latency and amplitude density of the P wave were not significantly different between the eyes with amblyopia and those with the contralateral eye. The latency of P wave in the lower half field of 1 ring, 2 ring, 3 ring and 4 ring were significantly longer than that in the normal group (P0.05), but the amplitude density had no statistical significance compared with the normal control group (P0.05). Conclusion 1. With the recovery of visual acuity to the normal level, the latency and amplitude density of the four characteristic peak P waves in the lower half visual field of the amblyopic eyes recovered to the same level as the contralateral eyes. 2. In the amblyopia and contralateral eyes of the cured monocular amblyopia, the latency and amplitude density of the P wave of the four eccentric mfVEP characteristic peaks in the lower half field were not significantly different, but the amblyopic eyes and the contralateral eyes were compared with the normal eyes respectively. Their latent period is still longer than that of normal people, indicating that the conduction pathway and visual cortex of amblyopia and contralateral eye are still abnormal in patients with monocular amblyopia. 3. In the amblyopia and contralateral eyes of the cured monocular amblyopia patients, there was no significant difference between the three groups in the P wave amplitude density of the four eccentric mfVEP characteristic peaks in the lower half field compared with the normal subjects. The results showed that the amplitude density of mfVEP in the cured monocular amblyopia patients returned to normal level earlier than the latent period.
【学位授予单位】：天津医科大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R777.44

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