奥洛他定联合普拉洛芬滴眼液治疗过敏性结膜炎的临床研究

发布时间：2018-07-25 14:16

【摘要】：目的：了解济南市眼科医院眼科门诊过敏性结膜炎的临床分布特征和应用0.1%盐酸奥洛他定联合0.1%普拉洛芬滴眼液治疗的初步效果。研究对象：济南市眼科医院眼科门诊294例过敏性结膜炎患者。 方法：将294例病例随机分成两组：对照组147例,单用0.1%奥洛他定滴眼液.试验组147例,联合应用0.1%普拉洛芬滴眼液与0.1%奥洛他定滴眼液,普拉洛芬每日点眼4次,奥洛他定每日点眼2次,每次1-2滴,两种药物间隔5分钟。于点药前、点药后30分钟、7天、14天评价患者症状和体征分值以及观察两组的有效率差别。 主要指标：过敏性结膜炎的临床类型特点、年龄分布、伴发过敏性鼻炎及过敏性哮喘的情况以及两组症状、体征分值比较,两组的有效率比较。 结果：过敏性结膜炎好发于中青年,12—55岁发病比例占84.7%,小于12岁少儿仅占6.1%,大于55岁患者占7.8%：患病与性别无关；有50%的患者同时伴有过敏性鼻炎,33.3%的患者同时伴有过敏性哮喘,16.3%的患者有家族史。临床分布中,常年性过敏性结膜炎和季节性过敏性结膜炎为主要的类型,占63.9%；年龄分布中,春季角结膜炎在儿童中占23.1%,明显高于成年人的6.6%,而特应性角膜结膜炎和巨乳头结膜炎所占的比例小于12.5%。 两组患者在治疗前的性别及症状、体征评分差异均无统计学意义(P0.05)。治疗前、治疗后30分钟,对照组与试验组的总评分值分别为21.95±3.01与21.84±3.34(P=0.7670),20.10±3.59与18.82±3.11(P=0.0013),两组比较无统计学差异。治疗后7天总评分值分别为11.89±3.96与8.39±3.39(P=0.0000),14天分别为9.25±4.18与5.29±3.56(P=0.0000),差异均有统计学意义(P0.01)。对照组与试验组在治疗7d后有效率分别为51.7%与66.0%；治疗14 d后有效率分别为72.1%及98.6%。差异均有非常显著的统计学意义(P0.01)。试验组未见明显用药后不适感与副作用。 结论：我国过敏性结膜炎好发于中青年。患病与性别无关。同时患有过敏性鼻炎及过敏性哮喘的比例较高。以常年性过敏性结膜炎和季节性过敏性结膜炎为主要类型,春季角结膜炎在儿童患病比例较高。0.1%盐酸奥洛他定联合0.1%普拉洛芬滴眼液对缓解过敏性结膜炎症状与体征具有显著效果,提高治疗的有效率,起效快,缩短用药时间,依从性好,无严重不良反应发生。
[Abstract]:Objective: to investigate the clinical distribution of allergic conjunctivitis in ophthalmological outpatient of Jinan Ophthalmology Hospital and the preliminary effect of 0.1% olotazidine hydrochloride combined with 0.1% Praproprofen eye drops in the treatment of allergic conjunctivitis. Participants: 294 patients with allergic conjunctivitis in ophthalmological clinic of Jinan Ophthalmology Hospital. Methods: 294 cases were randomly divided into two groups: control group (147 cases) with 0.1% olitadine eye drops. 147 patients in the trial group were treated with 0.1% Praproprofen eye drops and 0.1% oloatadine eye drops, 4 times a day for Praprofen and 1-2 drops for each time, and 2 times a day, with a 5 minute interval between the two drugs. The scores of symptoms and signs and the difference of effective rate between the two groups were evaluated before and 30 minutes after administration. Main outcome measures: clinical type, age distribution, allergic rhinitis and allergic asthma, as well as the scores of symptoms and signs of the two groups, the effective rate of the two groups were compared. Results: the incidence rate of allergic conjunctivitis was 84.7in the middle and young adults aged 12-55 years, only 6.1 in children younger than 12 years old, 7.8 in patients older than 55 years old: the disease had nothing to do with sex; 50% of the patients were accompanied with allergic rhinitis (33. 3%) and 16. 3% of the patients with allergic asthma (16. 3%) had a family history. In clinical distribution, perennial allergic conjunctivitis and seasonal allergic conjunctivitis were the main types, accounting for 63.9%. The proportion of keratoconjunctivitis in children in spring was 23.1cm, which was significantly higher than that in adults (6.6%), while the proportion of atopic keratoconjunctivitis and giant papillary conjunctivitis was less than 12.5%. There was no significant difference in the scores of gender, symptoms and signs between the two groups before treatment (P0.05). Before and 30 minutes after treatment, the total scores of control group and experimental group were 21.95 卤3.01 and 21.84 卤3.34 (P0. 7670), 20.10 卤3. 59 and 18. 82 卤3. 11 (P0. 0013), respectively. There was no significant difference between the two groups. The total scores were 11.89 卤3.96 and 8.39 卤3.39 (P0. 0000) and 9. 25 卤4. 18 and 5. 29 卤3. 56 (P0. 0000) on the 7th day after treatment, respectively. The difference was statistically significant (P0.01). The effective rates of the control group and the experimental group were 51.7% and 66.0% after 7 days treatment, and 72.1% and 98.6% after 14 days treatment, respectively. The difference was statistically significant (P0.01). There was no obvious discomfort and side effects in the test group. Conclusion: allergic conjunctivitis is more common in young and middle-aged people in China. The disease has nothing to do with sex. The proportion of allergic rhinitis and allergic asthma is high. The main types are perennial allergic conjunctivitis and seasonal allergic conjunctivitis. Spring keratoconjunctivitis has a significant effect on relieving symptoms and signs of allergic conjunctivitis with 0.1% olotaadine hydrochloride and 0.1% Praproprofen eye drops in children. The effective rate of treatment is improved, the effective rate is fast, and the time of medication is shortened. Compliance was good and no serious adverse reactions occurred.
【学位授予单位】：山东大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R777.3

【引证文献】

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1 关艳秋;;过敏性结膜炎应用奥洛他定联合普拉洛芬滴眼液的临床价值分析[J];中国卫生产业;2013年25期

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本文编号：2144084