承德市区居民鼾症和阻塞性睡眠呼吸暂停低通气综合征流行病学追踪调查
发布时间：2018-07-29 09:02
【摘要】： 阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)是睡眠期间反复出现的、短暂的、可逆的上气道狭窄或阻塞,引起呼吸暂停或低通气,有时伴有鼾声,引起日间过度嗜睡表现的一组症候群。鼾症(snoring disease)是鼾声响度超过60分贝以上,妨碍上呼吸道呼吸气流通过,影响同室人休息或导致他人烦恼的病症。打鼾是阻塞性睡眠呼吸暂停低通气综合征的一个十分突出的症状。 鼾症和OSAHS是呼吸系统的常见病和多发病,涉及到各年龄段人群,鼾症患病率为3%～48%;一般婴幼儿OSAHS的患病率为1%～3%,成年人OSAHS的患病率为2%～4%,而老年人OSAHS的患病率高达为20%～40%。鼾症与OSAHS主要是睡眠期间频繁呼吸暂停与低通气,引起慢性间歇低氧、高碳酸血症、胸腔负压增大、反复微觉醒及睡眠结构异常,导致自主神经功能紊乱、氧化应激及炎症反应、血管内皮细胞损伤、血流粘度增高、高凝状态、纤溶系统异常、泌尿生殖及内分泌代谢异常等一系列的临床症状及并发症。目前认为鼾症和OSAHS属于全身性疾病,而且作为心脑肺等血管疾病及代谢综合征等疾病的独立危险因素逐渐受到重视,并成为研究的热点;未经过治疗的鼾症与OSAHS患者睡眠中猝死增加。但鼾症和OSAHS属于慢性疾病,人们包括少数医务工作者在内对其所导致的心脑肺血管并发症乃至多脏器损害或疾病还缺乏足够的认识。 He J等对未治疗的OSAHS患者进行随访,发现AHI20次/h者5年病死率为11%～13%,8年病死率高达37%,而经气道切开和持续气道正压通气(CPAP)治疗者无1例死亡,而经过悬雍垂腭咽成形术(UPPP)治疗者6例死亡。鼾症与OSAHS严重影响患者的劳动能力、生活质量和生存率,并造成社会的重大经济负担。 为此,本研究对2002年承德市区鼾症和OSAHS调查人群进行7年随访,探讨鼾症和OSAHS对人群健康的影响,观察鼾症与非鼾症人群7年随访期间不同并发症的发病率和死亡率,分析其危险因素,并比较未接受治疗的OSAHS患者随访前后睡眠监测及临床特点的变化,为该病的防治提供理论依据。本研究包括两个部分: 第一部分:承德市区居民鼾症和非鼾症人群7年随访研究 第二部分:阻塞性睡眠呼吸暂停低通气综合征患者睡眠监测特点分析第一部分承德市区居民鼾症和非鼾症人群7年随访研究 目的: 探讨鼾症对人群健康的影响,观察鼾症和非鼾症人群7年随访期间不同并发症的发病率和死亡率,分析其危险因素,为该病的防治提供理论依据。 方法: 研究对象为2002年承德市区进行的鼾症和OSAHS流调人群1168人,于2009年2月～5月对其进行追踪随访,再次设计问卷进行入户调查。鼾症组共298人(包括死亡27人),非鼾症组共764人(包括死亡24人)。非鼾症组中有144人在7年随访期间出现鼾症(鼾级≥2级)。比较鼾症和非鼾症组7年随访期间并发症的发病率和死亡率,分析非鼾症组7年随访期间出现鼾症的危险因素(logistic回归分析),并进行认知情况比较。 结果: 1.鼾症组与非鼾症组7年随访期间不同并发症的发病率比较: 鼾症组7年随访期间高血压的发病率显著高于非鼾症组,分别为75.6%和17.4%,两组比较差异有统计学意义(P0.01);冠心病发病率分别为25.8%和7.2%,两组比较差异有统计学意义(P0.01);脑血管病发病率分别为21.8%和5.7%,两组比较差异有统计学意义(P0.01);糖尿病发病率分别为19.2%和4.2%,两组比较差异有统计学意义(P0.01);慢性肾脏病发病率分别为4.1%和0.5%,两组比较差异有统计学意义(P0.01)。 2.鼾症组与非鼾症组死于各种疾病的死亡率比较: 调查人群中共死亡51人,其中,鼾症组死亡27人,非鼾症组死亡24人,鼾症组的死亡率显著高于非鼾症组,分别为9.06%和3.87%,两组比较差异有统计学意义(P0.01)。其中,鼾症组和非鼾症组死于肿瘤的死亡率分别为2.3%和0.6%,两组比较差异有统计学意义(P0.05);脑血管病的死亡率分别为3.7%和1.0%,两组比较差异有统计学意义(P0.01);心血管病死亡率分别为3.0%和1.5%,两组比较差异无统计学意义(P0.05)。 3.非鼾症组7年随访期间出现鼾症的危险因素logistic回归分析:打鼾家族史、吸烟指数、体重指数与其鼾症的发生显著相关(P0.01),年龄与鼾症的发生相关(P0.05)。 4.鼾症认知情况:人群认为打鼾是病且需要治疗的2002年为25.34%,2009年为23.44%,两次调查结果比较,差异无统计学意义(P0.05)。 结论: 鼾症是高血压、冠心病、脑血管病、糖尿病和慢性肾脏病等疾病的高危因素。鼾症人群死亡率明显高于非鼾症人群。打鼾家族史、吸烟指数、体重指数、年龄是鼾症发生的危险因素。人们对鼾症与OSAHS的疾病认知情况仍没有明显改善。因此,应进一步加大宣传力度。 第二部分阻塞性睡眠呼吸暂停低通气综合征患者睡眠监测特点分析 目的: 分析未接受治疗的OSAHS患者7年随访前后睡眠监测及临床特点的变化。 方法: 研究对象为2002年承德市区流调及应用便携式睡眠监测仪确诊的99例OSAHS患者,包括中年组63例(男45例,女18例),老年组36例(男22例,女14例),均未接受治疗,7年后再次随访,行睡眠呼吸监测并分析其临床特点变化。 结果: 1.中年组和老年组7年前后严重程度和临床特点的变化 中年组OSAHS患者夜间憋醒的发生率高于老年组,差异有统计学意义(P0.05);中年组OSAHS患者白天嗜睡发生率与老年组比较,差异无统计学意义(P0.05);老年组OSAHS患者高血压的发生率高于中年组,差异有统计学意义(P0.05);老年组OSAHS患者冠心病、脑血管病、糖尿病的发生率显著高于中年组,差异有统计学意义(P0.01);中年组OSAHS患者的严重程度较7年前明显加重,差异有统计学意义(P0.01);老年组OSAHS患者的严重程度较7年前有加重趋势,但差异无统计学意义(P0.05)。 2.中年组和老年组OSAHS患者7年前后睡眠监测指标变化 (1)自身前后比较: 中年组OSAHS患者7年随访睡眠呼吸暂停低通气指数(AHI)从21.7次/h增高到30.2次/h,体重指数(BMI)、ESS评分均明显增加,睡眠时最低血氧饱和度(L SaO2)明显下降,7年前后比较差异均有统计学意义(P0.01); 老年组OSAHS患者AHI从25.6次/分增高到30.7次/分、BMI有增高趋势、ESS评分有减轻趋势,但7年前后差异均无统计学意义(P0.05);L SaO2较7年前明显下降,差异有统计学意义(P0.01)。 (2)组间变化值比较: 中年组OSAHS患者的AHI随访7年后上升值显著高于老年组,差异有统计学意义(P0.01)。中年组L SaO2随访7年后下降值显著高于老年组,差异有统计学意义(P0.01)。 结论: 未接受治疗的中年OSAHS患者随着年龄的增长,睡眠障碍的程度逐渐加重,而未治疗的老年OSAHS患者随着病程延长,睡眠障碍进展趋势有所减缓,但心脑血管等并发症明显增多。表明阻塞性睡眠呼吸暂停低通气综合征是一种潜在进展性疾病,应当早期治疗延缓病程进展,减少并发症的发生。
[Abstract]:Obstructive sleep apnea hypopnea syndrome (obstructive sleep apnea hypopnea syndrome, OSAHS) is a recurrent, transient, reversible upper airway stenosis or obstruction that causes apnea or hypoventilation, sometimes accompanied by snoring, and a group of symptoms that cause excessive daytime sleepiness. Snoring (snoring disease) is snoring. Snoring is a prominent symptom of obstructive sleep apnea hypopnea syndrome, which is more than 60 decibels, which hinders the passage of respiratory airflow in the upper respiratory tract and affects the rest of the same room or causes other people's troubles.
Snoring and OSAHS are common and frequently occurring diseases of the respiratory system. The prevalence of snoring is 3% to 48% in all age groups. The prevalence of OSAHS in children is 1% to 3%, and the prevalence rate of OSAHS in adults is 2% to 4%. The prevalence rate of OSAHS in the elderly is 20% to 40%. snoring and OSAHS is mainly the frequent apnea and low pass during sleep. Qi, caused by chronic intermittent hypoxia, hypercapnia, increased negative pressure of the thoracic cavity, repeated micro awakening and abnormal sleep structure, resulting in a series of clinical symptoms such as autonomic nervous dysfunction, oxidative stress and inflammation, vascular endothelial cell injury, blood flow viscosity, hypercoagulability, fibrinolysis, urogenital and endocrine and metabolic abnormalities. At present, snoring and OSAHS are considered as systemic diseases, and the independent risk factors such as cardiovascular and cerebropulmonary diseases and metabolic syndrome are gradually paid attention to, and become a hot spot of research. The snoring and OSAHS patients' sudden death in sleep are increased without treatment, but snoring and OSAHS are chronic diseases, people include A small number of medical workers lack sufficient knowledge of cardiovascular, cerebrovascular and pulmonary complications and even multiple organ damage or diseases.
He J and other untreated OSAHS patients were followed up and found that the 5 year fatality rate of the AHI20 /h was 11% to 13%, the 8 year fatality rate was 37%, and no 1 died by the airway incision and continuous positive airway pressure ventilation (CPAP), and 6 patients died through the uvulopalatopharyngoplasty (UPPP). Snoring and OSAHS seriously affected the patient's working ability. Live quality and survival rate, and cause great social financial burden.
For this purpose, this study conducted a 7 year follow-up study on snoring and OSAHS in Chengde in 2002 to investigate the effects of snoring and OSAHS on the health of the population, observe the incidence and mortality of different complications during the 7 year follow-up of snoring and non snoring people, analyze the risk factors, and compare the sleep monitoring before and after the follow-up of untreated OSAHS patients and The changes of clinical characteristics provide a theoretical basis for the prevention and treatment of the disease. This study includes two parts:
Part one: 7 year follow-up study on snoring and non snoring patients in Chengde urban area
The second part: analysis of the characteristics of sleep monitoring in patients with obstructive sleep apnea hypopnea syndrome the first part of the 7 year follow-up study of snoring and non snoring people in Chengde urban residents
Objective:
To investigate the effect of snoring on the health of the population, observe the incidence and mortality of different complications during the 7 year follow-up of snoring and non snoring people, analyze the risk factors and provide a theoretical basis for the prevention and treatment of the disease.
Method:
The subjects were 1168 snoring and OSAHS people in Chengde city in 2002. They were followed up from February 2009 to May and redesigned a questionnaire. 298 people in snoring group (including 27 deaths) and 764 non snoring groups (including 24 deaths). 144 people in non snoring group were snoring during the 7 year follow-up period (snoring). The incidence and mortality of complications during the 7 year follow-up of snoring and non snoring groups were compared. The risk factors of snoring during the 7 year follow-up of non snoring group (logistic regression analysis) were analyzed and the cognitive conditions were compared.
Result:
1. the incidence of different complications in snoring group and non snoring group during 7 years follow-up period:
During the 7 year follow-up, the incidence of hypertension in the snoring group was significantly higher than that in the non snoring group, 75.6% and 17.4%, respectively, and the two groups were statistically significant (P0.01), the incidence of coronary heart disease was 25.8% and 7.2%, the two groups were statistically significant (P0.01), and the incidence of cerebrovascular disease was 21.8% and 5.7%, respectively, and the two groups were statistically different. The incidence of diabetes mellitus (P0.01) was 19.2% and 4.2% respectively. The difference between the two groups was statistically significant (P0.01), and the incidence of chronic kidney disease was 4.1% and 0.5%, respectively, and the two groups had a significant difference (P0.01).
2. the mortality rate of snoring group and non snoring group died from various diseases:
Among the 51 people, 27 were killed in the snoring group and 24 in the non snoring group. The mortality rate of the snoring group was significantly higher than that of the non snoring group, 9.06% and 3.87% respectively. The two groups were statistically significant (P0.01). The mortality rate of the snoring and non snoring groups was 2.3% and 0.6% respectively, and the two groups were statistically different. The mortality of cerebrovascular disease was 3.7% and 1%, respectively, and the difference between the two groups was statistically significant (P0.01), the mortality of cardiovascular disease was 3% and 1.5%, respectively, and there was no significant difference between the two groups (P0.05).
The risk factors of snoring during the 7 year follow-up of 3. non snoring groups were analyzed by logistic regression analysis: the family history of snoring, smoking index, body mass index (BMI) and snoring were significantly related (P0.01), and age was associated with the occurrence of snoring (P0.05).
4. cognitive status of snoring: people think that snoring is a disease and the need for treatment in 2002 is 25.34%, 2009 is 23.44%, and the two survey results are compared, the difference is not statistically significant (P0.05).
Conclusion:
Snoring is a high risk factor for hypertension, coronary heart disease, cerebrovascular disease, diabetes, and chronic kidney disease. The mortality rate of snoring is significantly higher than that of non snoring people. Snoring family history, smoking index, body mass index, age are risk factors for snoring. People's cognition of snoring and OSAHS's disease is still not significantly improved. Therefore, Further increase the publicity.
The second part analysis of sleep monitoring characteristics in patients with obstructive sleep apnea hypopnea syndrome
Objective:
Objective to analyze the changes of sleep monitoring and clinical characteristics before and after 7 years of follow-up in OSAHS patients who had not received treatment.
Method:
The subjects were 99 patients with OSAHS in Chengde city in 2002, including 63 cases in the middle age group (45 men, 18 women), 36 cases in the elderly group (22 men and 14 women), all were not treated, and were followed up again after 7 years. The sleep breathing monitoring was performed and the changes of clinical characteristics were analyzed.
Result:
1. the changes of severity and clinical characteristics in the middle-aged group and the elderly group before and after 7 years.
The incidence of nocturnal waking of OSAHS patients in the middle age group was higher than that in the elderly group (P0.05); the incidence of daytime sleepiness in middle-aged group OSAHS patients was not statistically significant (P0.05) compared with the elderly group (P0.05); the incidence of hypertension in the elderly OSAHS patients was higher than that in the middle age group (P0.05); the coronary heart rate of the elderly patients with OSAHS was significantly higher than that in the elderly group (P0.05). The incidence of disease, cerebrovascular disease and diabetes was significantly higher than that in the middle age group (P0.01); the severity of OSAHS in the middle age group was significantly higher than that of 7 years ago, and the difference was statistically significant (P0.01); the severity of OSAHS in the elderly group was more severe than that of 7 years ago, but the difference was not statistically significant (P0.05).
2. the change of sleep monitoring index of OSAHS patients in middle age group and elderly group before and after 7 years.
(1) before and after the comparison:
The sleep apnea hypopnea index (AHI) increased from 21.7 times /h to 30.2 times in the middle age group of OSAHS patients, and the body mass index (BMI), ESS score increased significantly, and the lowest blood oxygen saturation (L SaO2) decreased significantly during sleep, and the difference was statistically significant (P0.01) before and after 7 years.
The AHI of OSAHS patients in the elderly group increased from 25.6 to 30.7 / min, BMI had a tendency to increase, and the ESS score had a decreasing trend, but there was no significant difference between 7 years and before (P0.05), and L SaO2 decreased significantly compared with 7 years ago, the difference was statistically significant (P0.01).
(2) the comparison of the change values between the groups:
The upward appreciation of AHI in middle age group OSAHS patients was significantly higher than that in the elderly group after 7 years. The difference was statistically significant (P0.01). The decline value of middle age group L SaO2 after 7 years was significantly higher than that in the elderly group, the difference was statistically significant (P0.01).
Conclusion:
Middle aged OSAHS patients with untreated age increased with age, and the degree of sleep disorders increased gradually, while the elderly OSAHS patients who were not treated prolonged with the duration of the disease, and the progression of sleep disorders slowed down, but the cardiovascular and cerebrovascular complications were significantly increased. The disease should be treated early to delay the progression of the disease and reduce the incidence of complications.
【学位授予单位】：承德医学院
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R766
本文编号：2152174
[Abstract]:Obstructive sleep apnea hypopnea syndrome (obstructive sleep apnea hypopnea syndrome, OSAHS) is a recurrent, transient, reversible upper airway stenosis or obstruction that causes apnea or hypoventilation, sometimes accompanied by snoring, and a group of symptoms that cause excessive daytime sleepiness. Snoring (snoring disease) is snoring. Snoring is a prominent symptom of obstructive sleep apnea hypopnea syndrome, which is more than 60 decibels, which hinders the passage of respiratory airflow in the upper respiratory tract and affects the rest of the same room or causes other people's troubles.
Snoring and OSAHS are common and frequently occurring diseases of the respiratory system. The prevalence of snoring is 3% to 48% in all age groups. The prevalence of OSAHS in children is 1% to 3%, and the prevalence rate of OSAHS in adults is 2% to 4%. The prevalence rate of OSAHS in the elderly is 20% to 40%. snoring and OSAHS is mainly the frequent apnea and low pass during sleep. Qi, caused by chronic intermittent hypoxia, hypercapnia, increased negative pressure of the thoracic cavity, repeated micro awakening and abnormal sleep structure, resulting in a series of clinical symptoms such as autonomic nervous dysfunction, oxidative stress and inflammation, vascular endothelial cell injury, blood flow viscosity, hypercoagulability, fibrinolysis, urogenital and endocrine and metabolic abnormalities. At present, snoring and OSAHS are considered as systemic diseases, and the independent risk factors such as cardiovascular and cerebropulmonary diseases and metabolic syndrome are gradually paid attention to, and become a hot spot of research. The snoring and OSAHS patients' sudden death in sleep are increased without treatment, but snoring and OSAHS are chronic diseases, people include A small number of medical workers lack sufficient knowledge of cardiovascular, cerebrovascular and pulmonary complications and even multiple organ damage or diseases.
He J and other untreated OSAHS patients were followed up and found that the 5 year fatality rate of the AHI20 /h was 11% to 13%, the 8 year fatality rate was 37%, and no 1 died by the airway incision and continuous positive airway pressure ventilation (CPAP), and 6 patients died through the uvulopalatopharyngoplasty (UPPP). Snoring and OSAHS seriously affected the patient's working ability. Live quality and survival rate, and cause great social financial burden.
For this purpose, this study conducted a 7 year follow-up study on snoring and OSAHS in Chengde in 2002 to investigate the effects of snoring and OSAHS on the health of the population, observe the incidence and mortality of different complications during the 7 year follow-up of snoring and non snoring people, analyze the risk factors, and compare the sleep monitoring before and after the follow-up of untreated OSAHS patients and The changes of clinical characteristics provide a theoretical basis for the prevention and treatment of the disease. This study includes two parts:
Part one: 7 year follow-up study on snoring and non snoring patients in Chengde urban area
The second part: analysis of the characteristics of sleep monitoring in patients with obstructive sleep apnea hypopnea syndrome the first part of the 7 year follow-up study of snoring and non snoring people in Chengde urban residents
Objective:
To investigate the effect of snoring on the health of the population, observe the incidence and mortality of different complications during the 7 year follow-up of snoring and non snoring people, analyze the risk factors and provide a theoretical basis for the prevention and treatment of the disease.
Method:
The subjects were 1168 snoring and OSAHS people in Chengde city in 2002. They were followed up from February 2009 to May and redesigned a questionnaire. 298 people in snoring group (including 27 deaths) and 764 non snoring groups (including 24 deaths). 144 people in non snoring group were snoring during the 7 year follow-up period (snoring). The incidence and mortality of complications during the 7 year follow-up of snoring and non snoring groups were compared. The risk factors of snoring during the 7 year follow-up of non snoring group (logistic regression analysis) were analyzed and the cognitive conditions were compared.
Result:
1. the incidence of different complications in snoring group and non snoring group during 7 years follow-up period:
During the 7 year follow-up, the incidence of hypertension in the snoring group was significantly higher than that in the non snoring group, 75.6% and 17.4%, respectively, and the two groups were statistically significant (P0.01), the incidence of coronary heart disease was 25.8% and 7.2%, the two groups were statistically significant (P0.01), and the incidence of cerebrovascular disease was 21.8% and 5.7%, respectively, and the two groups were statistically different. The incidence of diabetes mellitus (P0.01) was 19.2% and 4.2% respectively. The difference between the two groups was statistically significant (P0.01), and the incidence of chronic kidney disease was 4.1% and 0.5%, respectively, and the two groups had a significant difference (P0.01).
2. the mortality rate of snoring group and non snoring group died from various diseases:
Among the 51 people, 27 were killed in the snoring group and 24 in the non snoring group. The mortality rate of the snoring group was significantly higher than that of the non snoring group, 9.06% and 3.87% respectively. The two groups were statistically significant (P0.01). The mortality rate of the snoring and non snoring groups was 2.3% and 0.6% respectively, and the two groups were statistically different. The mortality of cerebrovascular disease was 3.7% and 1%, respectively, and the difference between the two groups was statistically significant (P0.01), the mortality of cardiovascular disease was 3% and 1.5%, respectively, and there was no significant difference between the two groups (P0.05).
The risk factors of snoring during the 7 year follow-up of 3. non snoring groups were analyzed by logistic regression analysis: the family history of snoring, smoking index, body mass index (BMI) and snoring were significantly related (P0.01), and age was associated with the occurrence of snoring (P0.05).
4. cognitive status of snoring: people think that snoring is a disease and the need for treatment in 2002 is 25.34%, 2009 is 23.44%, and the two survey results are compared, the difference is not statistically significant (P0.05).
Conclusion:
Snoring is a high risk factor for hypertension, coronary heart disease, cerebrovascular disease, diabetes, and chronic kidney disease. The mortality rate of snoring is significantly higher than that of non snoring people. Snoring family history, smoking index, body mass index, age are risk factors for snoring. People's cognition of snoring and OSAHS's disease is still not significantly improved. Therefore, Further increase the publicity.
The second part analysis of sleep monitoring characteristics in patients with obstructive sleep apnea hypopnea syndrome
Objective:
Objective to analyze the changes of sleep monitoring and clinical characteristics before and after 7 years of follow-up in OSAHS patients who had not received treatment.
Method:
The subjects were 99 patients with OSAHS in Chengde city in 2002, including 63 cases in the middle age group (45 men, 18 women), 36 cases in the elderly group (22 men and 14 women), all were not treated, and were followed up again after 7 years. The sleep breathing monitoring was performed and the changes of clinical characteristics were analyzed.
Result:
1. the changes of severity and clinical characteristics in the middle-aged group and the elderly group before and after 7 years.
The incidence of nocturnal waking of OSAHS patients in the middle age group was higher than that in the elderly group (P0.05); the incidence of daytime sleepiness in middle-aged group OSAHS patients was not statistically significant (P0.05) compared with the elderly group (P0.05); the incidence of hypertension in the elderly OSAHS patients was higher than that in the middle age group (P0.05); the coronary heart rate of the elderly patients with OSAHS was significantly higher than that in the elderly group (P0.05). The incidence of disease, cerebrovascular disease and diabetes was significantly higher than that in the middle age group (P0.01); the severity of OSAHS in the middle age group was significantly higher than that of 7 years ago, and the difference was statistically significant (P0.01); the severity of OSAHS in the elderly group was more severe than that of 7 years ago, but the difference was not statistically significant (P0.05).
2. the change of sleep monitoring index of OSAHS patients in middle age group and elderly group before and after 7 years.
(1) before and after the comparison:
The sleep apnea hypopnea index (AHI) increased from 21.7 times /h to 30.2 times in the middle age group of OSAHS patients, and the body mass index (BMI), ESS score increased significantly, and the lowest blood oxygen saturation (L SaO2) decreased significantly during sleep, and the difference was statistically significant (P0.01) before and after 7 years.
The AHI of OSAHS patients in the elderly group increased from 25.6 to 30.7 / min, BMI had a tendency to increase, and the ESS score had a decreasing trend, but there was no significant difference between 7 years and before (P0.05), and L SaO2 decreased significantly compared with 7 years ago, the difference was statistically significant (P0.01).
(2) the comparison of the change values between the groups:
The upward appreciation of AHI in middle age group OSAHS patients was significantly higher than that in the elderly group after 7 years. The difference was statistically significant (P0.01). The decline value of middle age group L SaO2 after 7 years was significantly higher than that in the elderly group, the difference was statistically significant (P0.01).
Conclusion:
Middle aged OSAHS patients with untreated age increased with age, and the degree of sleep disorders increased gradually, while the elderly OSAHS patients who were not treated prolonged with the duration of the disease, and the progression of sleep disorders slowed down, but the cardiovascular and cerebrovascular complications were significantly increased. The disease should be treated early to delay the progression of the disease and reduce the incidence of complications.
【学位授予单位】：承德医学院
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R766
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