感音神经性耳聋静息态功能磁共振研究

发布时间：2018-08-12 15:31

【摘要】： 目的:观察听力正常组和感音神经性耳聋组静息态脑功能激活区位置,并比较二者功能激活区位置有无差别。方法:采用GE3.0T磁共振系统,对24例听力正常被试者和24例感音神经性耳聋患者行常规T2WI和静息态脑功能磁共振扫描检查,观察脑功能激活区强度和MNI坐标,然后对所得数据进行相应统计学分析。结果:1.听力正常组:静息态ALFF激活脑区有:双侧额中回、双侧顶下小叶楔前叶、双侧顶下小叶、右侧扣带回前部、右侧扣带回后部及右侧额下回;静息态ReHo激活脑区有:双侧顶下小叶楔前叶、双侧顶叶角回、双侧扣带回后部、右侧扣带回前部、右侧额中回、右侧额下回。 2.感音神经性耳聋组:静息态ALFF激活脑区有:左侧额下回、左侧颞中回、左侧顶叶角回、右侧中央后回、右侧后扣带回;静息态ReHo激活脑区有:双侧枕叶皮层、左侧顶叶角回、左侧颞上回、左侧顶下小叶、右侧后扣带回、右侧前扣带回、右侧额中回、右侧顶下小叶缘上回。 3.听力正常组与感音神经性耳聋组比较:听力正常组比感音神经性耳聋ALFF激活程度强的脑区有:左侧额中回、左侧扣带回后部、右侧额上回、右侧额中回、右侧顶下小叶、右侧顶叶缘上回、右侧后扣带回;听力正常组比感音神经性耳聋ReHo激活程度强的脑区有:双侧额中回、双侧扣带回前部、左侧海马旁回、左侧顶叶缘上回、右侧顶下小叶、右侧中央后回。结论:1.听力正常人后扣带回及相邻的楔前叶、角回、腹侧前扣带回和前额叶静息状态了构成一个默认网络。 2.听力正常人和感音神经性耳聋患者ALFF和ReHo的脑部功能活区有所不同,说明感音神经性耳聋患者静息状下的默认网络发生了重组。
[Abstract]:Aim: to observe the location of resting brain activation area in normal hearing group and sensorineural deafness group, and to compare the difference between the two groups. Methods: using GE3.0T magnetic resonance system, 24 normal hearing subjects and 24 sensorineural deafness patients were examined by routine T2WI and resting brain functional magnetic resonance imaging, and the intensity of the activation area and the MNI coordinates were observed. Then the data are analyzed statistically. The result is 1: 1. In the normal hearing group, there were bilateral middle frontal gyrus, bilateral inferior parietal lobule, right anterior cingulate gyrus, right posterior cingulate gyrus and right inferior frontal gyrus. Resting ReHo activates the cerebral regions: bilateral inferior parietal lobulobule anterior lobe, bilateral parietal angular gyrus, bilateral posterior cingulate gyrus, right anterior cingulate gyrus, right middle frontal gyrus, right inferior frontal gyrus. Sensorineural hearing loss group: resting ALFF activated brain regions were left inferior frontal gyrus, left middle temporal gyrus, left parietal horn gyrus, right posterior central gyrus, right posterior cingulate gyrus, resting ReHo activated cerebral cortex, left parietal horn gyrus, bilateral occipital cortex, left parietal horn gyrus, Left superior temporal gyrus, left inferior parietal lobule, right posterior cingulate gyrus, right anterior cingulate gyrus, right middle frontal gyrus, right inferior parietal lobule superior gyrus. Compared with sensorineural hearing loss group, the areas of ALFF activation in normal hearing group were: left middle frontal gyrus, left posterior cingulate gyrus, right superior frontal gyrus, right middle frontal gyrus, right inferior parietal lobule, right superior frontal gyrus, right inferior parietal lobe, right frontal gyrus, right superior frontal gyrus, right inferior parietal lobule. In the right superior parietal lobe gyrus, the right posterior cingulate gyrus; in the normal hearing group, there were more active ReHo in bilateral middle frontal gyrus, bilateral anterior cingulate gyrus, left parahippocampal gyrus, left superior parietal lobe gyrus, right inferior parietal lobe, and right inferior parietal lobe. Right posterior central gyrus. Conclusion 1. In normal hearing people, the posterior cingulate gyrus and adjacent precuneal lobe, angular gyrus, ventral anterior cingulate gyrus and prefrontal lobe rest state constitute a default network. 2. The difference between the active regions of brain function of ALFF and ReHo in normal hearing patients and sensorineural deafness patients suggests that the default network in patients with sensorineural hearing loss has been reorganized.
【学位授予单位】：河北医科大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R764

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