OSAHS患者血浆褪黑激素与其脑电觉醒的相关性及在白天嗜睡程度评估中的价值
发布时间：2018-09-13 16:00
【摘要】：目的:探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血浆褪黑激素水平与脑电觉醒指数、呼吸暂停低通气指数(AHI)及最低血氧饱和度之间的关系;探讨褪黑激素水平在OSAHS患者白天嗜睡程度评估中的价值。 方法:选取2007年～2009年在我院行多导睡眠监测(PSG)的患者87例(其中17例为对照组,70例为OSAHS患者)。早晨6点取静脉血2ml,用酶联免疫分析方法检测血浆褪黑激素水平。参照美国睡眠医学会标准,根据PSG监测结果将OSAHS患者分为轻、中、重、极重度四组,其中轻度11例,中度14例,重度19例,极重度26例;对照组17例根据PSG及有无打鼾分为正常对照组及单纯鼾症对照组,其中正常对照组11例,单纯鼾症对照组6例。 结果:①OSAHS患者与对照组相比,血浆褪黑激素水平升高有统计学意义(P0.05);②血浆褪黑激素水平与脑电觉醒指数及AHI值呈正相关,与最低血氧饱和度呈负相关,且均有统计学意义(P0.05)。③血浆褪黑激素水平与ESS评分呈正相关,经统计学检验无统计学意义(P0.05)。 结论:OSAHS患者血浆褪黑激素水平升高,且褪黑激素水平与OSAHS患病程度有密切联系;褪黑激素水平可反映患者白天嗜睡程度,对OSAHS患者白天嗜睡程度评估可能有重要价值。
[Abstract]:Objective: to investigate the relationship between plasma melatonin level and EEG arousal index, apnea hypopnea index (AHI) and minimum oxygen saturation in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). To investigate the value of melatonin level in daytime sleepiness in OSAHS patients. Methods: 87 patients with polysomnography (PSG) were selected from 2007 to 2009 in our hospital (17 cases were control group, 70 cases were OSAHS patients). Plasma melatonin levels were detected by enzyme linked immunosorbent assay (Elisa). According to the standard of American Sleep Medical Association, OSAHS patients were divided into four groups according to the results of PSG monitoring: mild, moderate, severe, and extremely severe, 11 mild, 14 moderate, 19 severe and 26 extremely severe. According to PSG and snoring, 17 cases in control group were divided into normal control group and simple snoring control group, including 11 normal control group and 6 simple snoring control group. Results compared with the control group, the plasma melatonin level was significantly increased (P0.05). The plasma melatonin level was positively correlated with the EEG arousal index and AHI, and negatively correlated with the lowest oxygen saturation. There was a positive correlation between plasma melatonin level and ESS score (P0.05), but there was no statistical significance by statistical test (P0.05). Conclusion the plasma melatonin level is increased in patients with OSAHS and melatonin level is closely related to the severity of OSAHS. Melatonin level may reflect daytime sleepiness in patients with OSAHS and may be of great value in the evaluation of daytime sleepiness in OSAHS patients.
【学位授予单位】：华中科技大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R766
本文编号：2241655
[Abstract]:Objective: to investigate the relationship between plasma melatonin level and EEG arousal index, apnea hypopnea index (AHI) and minimum oxygen saturation in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). To investigate the value of melatonin level in daytime sleepiness in OSAHS patients. Methods: 87 patients with polysomnography (PSG) were selected from 2007 to 2009 in our hospital (17 cases were control group, 70 cases were OSAHS patients). Plasma melatonin levels were detected by enzyme linked immunosorbent assay (Elisa). According to the standard of American Sleep Medical Association, OSAHS patients were divided into four groups according to the results of PSG monitoring: mild, moderate, severe, and extremely severe, 11 mild, 14 moderate, 19 severe and 26 extremely severe. According to PSG and snoring, 17 cases in control group were divided into normal control group and simple snoring control group, including 11 normal control group and 6 simple snoring control group. Results compared with the control group, the plasma melatonin level was significantly increased (P0.05). The plasma melatonin level was positively correlated with the EEG arousal index and AHI, and negatively correlated with the lowest oxygen saturation. There was a positive correlation between plasma melatonin level and ESS score (P0.05), but there was no statistical significance by statistical test (P0.05). Conclusion the plasma melatonin level is increased in patients with OSAHS and melatonin level is closely related to the severity of OSAHS. Melatonin level may reflect daytime sleepiness in patients with OSAHS and may be of great value in the evaluation of daytime sleepiness in OSAHS patients.
【学位授予单位】：华中科技大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R766
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