金纳多联合激素治疗对不同听力曲线类型突聋伴耳鸣患者的疗效观察
发布时间：2018-09-17 18:37
【摘要】： 目的：通过对111例不同听力曲线类型突聋伴主观性耳鸣患者使用金纳多联合激素治疗后对耳鸣疗效、听力疗效、综合疗效三方面的研究,评价此类治疗方案在不同听力曲线类型耳鸣患者中的应用价值。为今后临床使用此类药物治疗筛选合适的病例,这也是为广大耳鸣患者个性化治疗方案提供参考依据。 方法：研究2008年8月～2009年10月在我科住院治疗的以主观性耳鸣及听力下降为主诉的突聋患者111例。按照听力曲线类型分为3个研究组：下降型组42例,上升型组37例,平坦型组32例。所有病例均使用金纳多联合地塞米松激素治疗,平均治疗(11.7±3.0)天。 结果：经卡方检验表明,3个研究组间,耳鸣疗效x2=19.713、听力疗效x2=44.265、综合疗效x2=14.956,P值均0.05,差异有统计学意义,说明3组不同听力曲线类型的耳鸣患者治疗效果不同。上升型组在耳鸣疗效、听力疗效及综合疗效三方面评价结果提示对金纳多联合激素治疗较为敏感。 结论：对上升型听力曲线的耳鸣患者推荐使用金纳多联合激素治疗,而下降型听力曲线和平坦型听力曲线的耳鸣患者使用金纳多联合激素治疗的疗效有限。
[Abstract]:Objective: to study the curative effect, hearing effect and comprehensive curative effect on tinnitus in 111 patients with sudden hearing loss and subjective tinnitus. To evaluate the value of this treatment regimen in patients with tinnitus with different hearing curve types. It provides a reference for individualized treatment of tinnitus patients. Methods: 111 cases of sudden deafness with subjective tinnitus and hearing loss in our department from August 2008 to October 2009 were studied. According to the type of hearing curve, they were divided into three groups: descending group (n = 42), ascending type group (n = 37) and flat type group (n = 32). All patients were treated with Ginaton combined with dexamethasone with an average of (11.7 卤3.0) days. Results: the chi-square test showed that the tinnitus curative effect x219.713, the hearing curative effect x24.265, the comprehensive curative effect x24.956 P value were 0.05, the difference was statistically significant, which indicated that the three groups of tinnitus patients with different hearing curve types had different therapeutic effects. The evaluation of tinnitus effect, hearing effect and comprehensive curative effect in ascending type group indicated that it was more sensitive to the combination of Ginaton and hormone therapy. Conclusion: it is recommended to treat tinnitus patients with ascending hearing curve by combination of kinnardo and hormone, while those with reduced hearing curve and flat hearing curve have limited curative effect.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R764
[Abstract]:Objective: to study the curative effect, hearing effect and comprehensive curative effect on tinnitus in 111 patients with sudden hearing loss and subjective tinnitus. To evaluate the value of this treatment regimen in patients with tinnitus with different hearing curve types. It provides a reference for individualized treatment of tinnitus patients. Methods: 111 cases of sudden deafness with subjective tinnitus and hearing loss in our department from August 2008 to October 2009 were studied. According to the type of hearing curve, they were divided into three groups: descending group (n = 42), ascending type group (n = 37) and flat type group (n = 32). All patients were treated with Ginaton combined with dexamethasone with an average of (11.7 卤3.0) days. Results: the chi-square test showed that the tinnitus curative effect x219.713, the hearing curative effect x24.265, the comprehensive curative effect x24.956 P value were 0.05, the difference was statistically significant, which indicated that the three groups of tinnitus patients with different hearing curve types had different therapeutic effects. The evaluation of tinnitus effect, hearing effect and comprehensive curative effect in ascending type group indicated that it was more sensitive to the combination of Ginaton and hormone therapy. Conclusion: it is recommended to treat tinnitus patients with ascending hearing curve by combination of kinnardo and hormone, while those with reduced hearing curve and flat hearing curve have limited curative effect.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R764
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