注射用鼠神经生长因子多药联合治疗对缺血性视神经病变的作用

发布时间：2018-10-11 07:57

【摘要】：目的:探讨鼠神经生长因子多药联合治疗缺血性视神经病变的疗效。方法:选取2012年11月-2013年11月收治的120例(120眼)缺血性视神经病变患者作为研究对象,按收治时间顺序分为联合组和对照组,各60例,对照组给予常规药物治疗,联合组在常规药物治疗基础上,加用鼠神经生长因子,比较2组患者的疗效及不良反应。结果:联合组患者的治疗总有效率为96.7%,显著高于对照组的78.3%,P0.05,差异具有统计学意义;治疗期间,联合组有13例发生注射不良事件,其中臀部疼痛1例,注射部位硬结、红肿、疼痛12例,实验室指标不良事件4例(6.7%)。结论:注射用鼠神经生长因子多药联合治疗缺血性视神经病变,具有确切的疗效,且不良反应少,是一种安全、有效的治疗方案。
[Abstract]:Objective: to investigate the effect of nerve growth factor (NGF) combined with multiple drugs in the treatment of ischemic optic neuropathy. Methods: 120 cases (120 eyes) of ischemic optic neuropathy from November 2012 to November 2013 were selected and divided into two groups according to the time order: the combined group (n = 60) and the control group (n = 60). On the basis of routine drug therapy, the combined group was treated with nerve growth factor (NGF), and the curative effect and adverse reaction were compared between the two groups. Results: the total effective rate of treatment in the combined group was 96.7g, which was significantly higher than that in the control group (78.3%, P0.05), the difference was statistically significant, and during the treatment, 13 cases of adverse events occurred in the combined group, including 1 case of hip pain, 1 case of induration at injection site, and 1 case of redness and swelling. There were 12 cases of pain and 4 cases of adverse events (6.7%). Conclusion: it is safe and effective to treat ischemic optic neuropathy with multiple drugs of nerve growth factor for injection.
【作者单位】：浙江省德清县第三人民医院;浙江大学医学院附属第二医院;
【分类号】：R774.6

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