湿性年龄相关性黄斑变性疾病的视网膜电位特征
发布时间：2018-10-11 09:06
【摘要】：目的：视网膜电图(electroretinogram, ERG)是一种客观反应视网膜功能的无创性检查。比较湿性年龄相关性黄斑变性（wet-AMD）患者的ERG检查中a、b波振幅、潜时与正常人间的差异,明确湿性AMD患者的ERG特点。同时比较不同程度AMD病变患者ERG的a、b波振幅和潜时差异，观察ERG各参数与病变程度间的关系。 方法：对照组12例（14眼）和AMD患者组16人（18眼）均行矫正视力、裂隙灯、ERG及眼底检查，AMD患者同时行眼视网膜血管造影（FFA）、眼脉络膜血管造影（ICG）及光学相干断层扫描(OCT)检查，并根据OCT结果将AMD患者分3组，分别记录AMD患者与正常组及AMD患者组内暗适应和明适应3.0时a、b波的振幅及潜时，用SPSS17.00软件分析各组参数间的差异性。 结果：AMD组与对照组比较暗适应3.0时a波振幅P值为0.002,潜时P值为0.084，b波振幅P值为0.000,潜时P值为0.054；明适应3.0时a波振幅P值为0.000,潜时P值为0.000，b波振幅P值为0.000,潜时P值为0.059。AMD患者根据OCT结果分组比较：暗适应3.0时a波振幅P值为0.555,潜时P值为0.432，b波振幅P值为0.291,潜时P值为0.385；明适应3.0时a波振幅P值为0.236,潜时P值为0.001，b波振幅P值为0.045,潜时P值为0.138。 结论：与正常人相比湿性AMD患者a、b波振幅明显降低，这与视锥、视杆系统损伤相关。明适应ERG是在湿性AMD病变中反应较敏感，，但能否将ERG作为湿性AMD病变分级的指标需进一步研究。
[Abstract]:Objective: electroretinogram (electroretinogram, ERG) is a non-invasive examination of retinal function. To compare the amplitude and latent time of ERG in ERG of patients with wet age-related macular degeneration (wet-AMD), and to determine the characteristics of ERG in the patients with wet age related macular degeneration (wet-AMD). At the same time, the amplitude and latent time of ERG in patients with different degrees of AMD lesions were compared, and the relationship between the parameters of ERG and the degree of lesion was observed. Methods: visual acuity, slit lamp, ERG and fundus examination were performed in 12 patients (14 eyes) in the control group and 16 eyes (18 eyes) in the AMD group. Retinal angiography (FFA), choroidal angiography (ICG) and optical coherence tomography (OCT) were performed in AMD patients. According to the results of OCT, the patients with AMD were divided into three groups. The amplitude and latent time of dark adaptation and light adaptation were recorded in AMD group, normal group and AMD group respectively. The difference of parameters in each group was analyzed by SPSS17.00 software. Results: compared with the control group, the amplitude of a wave (P = 0.002), latent time (P = 0.084) and latent time (P = 0.054) in AMD group were compared with those in control group. A wave amplitude P was 0.000, latent P value was 0.000b wave amplitude P value was 0.0000.000, latent P value of 0.059.AMD patients was compared according to OCT results: a wave amplitude P value was 0.555 at dark adaptation 3.0, latent P value was 0.432b wave amplitude P value was 0.291, latent P value was 0.385; The amplitude of a wave P is 0.236, the latent P value is 0.001kb wave amplitude P is 0.045, and the latent P value is 0.138. Conclusion: the amplitude of AGB wave in wet AMD patients is significantly lower than that in normal subjects, which is related to the injury of optic cone and rod system. Light adaptive ERG is more sensitive in the pathological changes of AMD, but whether ERG can be used as the index of pathological grading of wet AMD needs further study.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R774.1
本文编号：2263625
[Abstract]:Objective: electroretinogram (electroretinogram, ERG) is a non-invasive examination of retinal function. To compare the amplitude and latent time of ERG in ERG of patients with wet age-related macular degeneration (wet-AMD), and to determine the characteristics of ERG in the patients with wet age related macular degeneration (wet-AMD). At the same time, the amplitude and latent time of ERG in patients with different degrees of AMD lesions were compared, and the relationship between the parameters of ERG and the degree of lesion was observed. Methods: visual acuity, slit lamp, ERG and fundus examination were performed in 12 patients (14 eyes) in the control group and 16 eyes (18 eyes) in the AMD group. Retinal angiography (FFA), choroidal angiography (ICG) and optical coherence tomography (OCT) were performed in AMD patients. According to the results of OCT, the patients with AMD were divided into three groups. The amplitude and latent time of dark adaptation and light adaptation were recorded in AMD group, normal group and AMD group respectively. The difference of parameters in each group was analyzed by SPSS17.00 software. Results: compared with the control group, the amplitude of a wave (P = 0.002), latent time (P = 0.084) and latent time (P = 0.054) in AMD group were compared with those in control group. A wave amplitude P was 0.000, latent P value was 0.000b wave amplitude P value was 0.0000.000, latent P value of 0.059.AMD patients was compared according to OCT results: a wave amplitude P value was 0.555 at dark adaptation 3.0, latent P value was 0.432b wave amplitude P value was 0.291, latent P value was 0.385; The amplitude of a wave P is 0.236, the latent P value is 0.001kb wave amplitude P is 0.045, and the latent P value is 0.138. Conclusion: the amplitude of AGB wave in wet AMD patients is significantly lower than that in normal subjects, which is related to the injury of optic cone and rod system. Light adaptive ERG is more sensitive in the pathological changes of AMD, but whether ERG can be used as the index of pathological grading of wet AMD needs further study.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R774.1
【参考文献】
相关期刊论文 前2条
1 陈慧慧,唐罗生;视网膜的年龄相关性改变[J];国际眼科杂志;2004年04期
2 施晨蕾;王亚冬;;湿性年龄相关性黄斑变性患者光感受器细胞层变化与视力的相关性研究[J];眼科新进展;2013年11期
本文编号：2263625
本文链接：https://www.wllwen.com/yixuelunwen/yank/2263625.html
最近更新
教材专著
