凝集素样氧化低密度脂蛋白受体-1与男性阻塞性睡眠呼吸暂停低通气综合征的相关性

发布时间：2018-10-23 13:02

【摘要】：目的:研究凝集素样氧化低密度脂蛋白受体-1(sLOX-1)在男性阻塞性睡眠呼吸暂停低通气综合征患者(OSAHS)中的水平。方法:选取2011年9月-2012年6月于武汉大学人民医院鼾症中心住院的102例男性患者行多导睡眠监测,进一步分为轻度组(n=24),中度组(n=14)和重度组(n=64)。ELISA法监测患者血清sLOX-1水平,并在1月后随访。结果:对正常对照组、轻度和中度OSAHS患者相比,重度OSAHS患者血清sLOX1水平升高,血清sLOX1水平与夜间平均血压、总甘油三酯(TG)、呼吸暂停低通气指数(AHI)、最低血氧饱和度(LSaO2)水平呈正相关。1个月后随访,重度OSAHS患者血清sLOX1水平明显降低(P0.001)。结论:血清sLOX-1与重度OSAHS密切相关,男性阻塞性睡眠呼吸暂停低通气综合征患者sLOX-1水平升高。
[Abstract]:Aim: to study the level of lectin like oxidized low density lipoprotein receptor-1 (sLOX-1) in (OSAHS) of male patients with obstructive sleep apnea hypopnea syndrome (OSAS). Methods: from September 2011 to June 2012, 102 male patients admitted to the snoring center of Renmin Hospital of Wuhan University were selected for polysomnography monitoring. The patients were further divided into three groups: mild group (n = 24), moderate group (n = 14) and severe group (n = 64). ELISA). They were followed up after 1 month. Results: in normal control group, compared with mild and moderate OSAHS patients, the serum sLOX1 level in severe OSAHS patients was higher than that in mild and moderate OSAHS patients, and the serum sLOX1 level was higher than that in nocturnal mean blood pressure. Total triglyceride (TG), apnea-hypopnea index (AHI),) minimum oxygen saturation (LSaO2) level was positively correlated. After 1 month follow-up, the serum sLOX1 level in patients with severe OSAHS was significantly decreased (P0. 001). Conclusion: serum sLOX-1 is closely related to severe OSAHS, and the level of sLOX-1 in male patients with obstructive sleep apnea hypopnea syndrome is higher.
【作者单位】：武汉大学人民医院心血管内科;武汉大学人民医院耳鼻喉头颈外科;
【基金】：国家创新性大学生科研项目(编号:101048637)
【分类号】：R766

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