HLA基因配型与高危角膜移植排斥关系的Meta分析

发布时间：2018-10-31 09:15

【摘要】：目的:探讨角膜移植术前人类白细胞抗原(human leucocyte antigen,HLA)氨基酸残基配型与术后排斥反应的相关性。方法:运用循证医学的研究方法检索美国国立医学图书馆(PubMed数据库)、循证医学数据库(Cochrane library)、Web of knowledge数据库、中国知网(CNKI),中国生物医学文献数据库和Google学术搜索,收集有关随机对照与非随机对照试验,根据评价结果进行Meta分析。统计分析采用RevMan 5.0软件。结果:共纳入病例对照研究9篇(1 128只眼),配型组与对照组术后临床疗效比较:HLA-A配型组术后角膜移植排斥反应的眼数比对照组少(P0.000 01);术前进行HLA-B配对组比对照组发生排斥反应的眼数少(P0.000 01);术前进行HLA-DR配型比对照组发生排斥反应少(P0.000 01)。结论:在高危角膜移植患者中,术前进行HLA-A、HLA-B、HLA-DR位点配型的排斥反应明显低于对照组,术前进行HLA配型有临床指导意义。
[Abstract]:Objective: to investigate the relationship between the amino acid residues of human leukocyte antigen (human leucocyte antigen,HLA) before corneal transplantation and postoperative rejection. Methods: the National Library of Medicine (PubMed), the Evidence-based Medicine Database (Cochrane library), Web of knowledge), the Chinese Biomedical Literature Database (CNKI),) and the Google academic search were searched by Evidence-based Medicine (EBM). Meta analysis was carried out according to the results of random controlled and non-randomized controlled trials. RevMan 5.0 software was used for statistical analysis. Results: nine articles (1 128 eyes) were included in the case-control study. Compared with the control group, the number of eyes with corneal allograft rejection in the HLA-A matching group was less than that in the control group (P0. 00001). The number of eyes with preoperative HLA-B matching group was less than that of control group (P0.00001), and the preoperative HLA-DR matching group had less rejection reaction than the control group (P0.00001). Conclusion: in the patients with high risk corneal transplantation, the rejection of preoperative HLA-A,HLA-B,HLA-DR matching is significantly lower than that of the control group, and the preoperative HLA matching is of clinical significance.
【作者单位】：暨南大学附属第一医院眼科;
【分类号】：R779.65

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