前列腺素受体基因多态性与曲伏前列腺素降眼压疗效的相关性

发布时间：2018-11-09 15:58

【摘要】：目的观察前列腺素受体基因(PTGFR)多态性与曲伏前列腺素降眼压疗效的相关性。方法纳入50例原发性开角型青光眼或高眼压症患者,用PCR产物直接测序法对PTGFR基因的第2,3,4外显子测序及位于启动子的4个SNPs位点rs3753380、rs3766355、rs1073610、rs1073611、位于第1内含子的rs3766355等位点进行基因分型;分析其与曲伏前列腺素降眼压疗效的关系。结果PTGFR基因的第2,3,4外显子未发现突变位点,2例在rs1073610G/A、rs1073611A/G发现突变位点。rs3766355C/A位点基因多态性与基线眼压相关(P0.05);在高眼压症患者中rs3753380T/C位点、rs3766355A/C位点基因多态性与曲伏前列腺素降眼压疗效相关。结论 PTGFR基因rs373380位点、rs3766355位点基因多态性与高眼压症患者使用曲伏前列腺素的降眼压疗效相关。
[Abstract]:Objective to investigate the relationship between (PTGFR) polymorphism of prostaglandin receptor gene and the effect of travoprostaglandin on intraocular pressure (IOP). Methods 50 patients with primary open-angle glaucoma or intraocular hypertension were included. The exon 2 of PTGFR gene was sequenced by direct PCR product sequencing, and the rs3753380,rs3766355,rs1073610,rs1073611, was located at four SNPs sites of promoter. The rs3766355 alleles located at intron 1 were genotyped. To analyze the relationship between prostaglandin and travoprostaglandin in the treatment of intraocular pressure (IOP). Results No mutation site was found in exon 2 of PTGFR gene, 2 cases were found mutation site in rs1073610G/A,rs1073611A/G. The polymorphism of rs3766355C/A locus was associated with baseline IOP (P0.05). The polymorphism of rs3753380T/C locus and rs3766355A/C locus gene was associated with the effect of travoprostaglandin lowering intraocular pressure (IOP) in patients with intraocular hypertension (IOP). Conclusion the polymorphism of rs373380 locus and rs3766355 locus of PTGFR gene is associated with the effect of travoprostaglandin on intraocular pressure reduction in patients with intraocular hypertension.
【作者单位】：首都医科大学附属北京同仁医院国家药物临床试验机构;首都医科大学附属北京同仁医院眼科中心;北京市眼科研究所;
【基金】：十二五“重大新药创制”国家科技重大专项基金资助项目(2011ZX09302-007-05)
【分类号】：R775

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