糖尿病视网膜病变患者血浆血栓调节蛋白和D-二聚体水平的研究

发布时间：2018-11-14 14:37

【摘要】：目的探讨血栓调节蛋白(TM)和D-二聚体(D-D)与DR的关系。方法将60例糖尿病患者按眼底视网膜病变程度分为糖尿病无视网膜病变期(NDR),单纯型糖尿病视网膜病变期(SDR)和增殖型糖尿病视网膜病变期(PDR)。另选健康者30名作为正常对照(NC)组。测定各组血浆TM浓度及D-D浓度,同时研究TM与D-D的相关性。结果 (1)NDR、SDR和PDR组血浆TM水平[(27.17±18.30)、(39.67±18.41)和(61.83±24.31)ng/ml]均高于NC组[(15.63±13.79)ng/ml](P0.05);(2)NDR组血浆D-D水平[(0.19±0.07)μg/ml]与NC组[(0.17±0.06)μg/ml]比较,差异无统计学意义(P0.05);SDR、PDR组[(0.24±0.06)、(0.57±0.09)μg/ml]均高于NDR组与NC组(P0.05);(3)血浆TM与D-D呈正相关(r=0.508,P0.01)。结论检测血浆TM及D-D水平可帮助评价糖尿病患者血管内皮细胞损伤的情况,以及眼底视网膜病变程度,同时可反映体内是否存在高凝状态。
[Abstract]:Objective to investigate the relationship between thrombomodulin (TM) and D-dimer (D-D) and DR. Methods 60 patients with diabetic retinopathy were divided into (NDR), without retinopathy and (SDR) with proliferative diabetic retinopathy and (PDR). With proliferative diabetic retinopathy according to the degree of retinopathy. Another 30 healthy subjects were selected as normal control (NC) group. The plasma levels of TM and D-D were measured and the correlation between TM and D-D was studied. Results (1) the plasma TM levels in NDR,SDR and PDR groups [(27.17 卤18.30), () 39.67 卤18.41 ng/ml and (61.83 卤24.31) ng/ml] were higher than those in NC group [(15.63 卤13.79) ng/ml] (P0.05). (2) the level of D-D in NDR group [(0.19 卤0.07) 渭 g/ml] was not significantly different from that in NC group [(0.17 卤0.06) 渭 g/ml] (P0.05). There was a positive correlation between plasma TM and D-D in SDR,PDR group [(0.24 卤0.06), () 0.57 卤0.09 渭 g/ml] compared with NDR group and NC group (P0.05); (3, P 0.01). Conclusion Detection of plasma TM and D-D levels may be helpful to evaluate vascular endothelial cell injury and the degree of retinopathy in diabetic patients, and to reflect whether hypercoagulable state exists in the body.
【作者单位】：包头医学院第一附属医院内分泌科;
【基金】：包头市社会发展科技支撑项目(2012S2006-04-04)
【分类号】：R587.2;R774.1

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