单侧感音神经性耳聋患者低频振幅功能磁共振研究

发布时间：2018-11-17 21:41

【摘要】：目的应用低频振幅分析方法来观察长期右侧感音神经性耳聋患者静息态脑功能磁共振的改变。方法采集19例中重度右侧感音神经性耳聋患者以及20名正常听力志愿者的静息态磁共振血氧水平依赖(blood oxygenationlevel dependent,BOLD)数据采集,对BOLD数据进行后处理以获得低频振幅波动(amplitude of low-frequency fluctua-tion,ALFF)图像,并比较两组间ALFF信号的差异性。结果右侧耳聋组较正常听力对照组ALFF增加且差异具有统计学意义(P0.05,AlphaSim校正)的脑区包括在双侧颞上中回(双侧颞横回与双侧颞极)、双侧岛叶、双侧钩回、右海马旁回以及小脑前叶。右侧耳聋组较正常听力对照组ALFF减低且差异具有统计学意义(P0.05,AlphaSim校正)的脑区包括右侧颞中回后部。结论右侧感音神经性耳聋患者相关脑区的脑功能活动水平与正常听力人群的不同提示了耳聋后脑代偿性功能改变的存在。
[Abstract]:Objective to observe the changes of resting brain functional magnetic resonance (Mr) in patients with long term right sensorineural deafness by low frequency amplitude analysis. Methods data were collected from 19 moderate and severe right sensorineural hearing loss patients and 20 normal hearing volunteers. The low frequency amplitude fluctuation (amplitude of low-frequency fluctua-tion,ALFF) images were obtained by post-processing of BOLD data, and the differences of ALFF signals between the two groups were compared. Results the ALFF of the right deafness group was significantly higher than that of the normal hearing control group (P 0.05 AlphaSim correction), including bilateral superior middle temporal gyrus (bilateral transverse temporal gyrus and bilateral temporal pole), bilateral insular lobe and bilateral hook gyrus. Right parahippocampal gyrus and anterior cerebellar lobe. The ALFF of the right deafness group was significantly lower than that of the normal hearing control group (P 0.05 AlphaSim correction) including the posterior part of the right middle temporal gyrus. Conclusion the difference of brain function activity between right sensorineural hearing loss patients and normal hearing population suggests the existence of compensatory changes in brain function after deafness.
【作者单位】：东南大学附属中大医院放射科;东南大学附属中大医院耳鼻喉及头颈外科;
【基金】：国家自然科学基金面上项目(30970808)
【分类号】：R764.431

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