鼻腔-鼻窦鳞状细胞癌中PDCD5和Bcl-2蛋白的表达及意义

发布时间：2018-11-21 08:59

【摘要】：目的:研究程序性细胞死亡因子5(PDCD5)及Bcl-2蛋白在鼻腔、鼻窦鳞状细胞癌(SNSCC)中的表达及临床意义。方法:采用免疫组织化学SP法及Western blot技术分别检测46例SNSCC组织(SNSCC组),38例鼻腔、鼻窦内翻性乳头状瘤组织(SNIP组)中以及20例正常鼻腔黏膜(正常组)中PDCD5和Bcl-2蛋白的表达情况。结果:1与SNIP组及正常组相比,SNSCC组中PDCD5蛋白的表达明显下调,Bcl-2蛋白的表达明显上调;2在SNSCC组中,PDCD5蛋白及Bcl-2蛋白在高、中分化与低分化组中的阳性表达率分别是100.00%、83.33%、38.89%以及50.00%、70.83%、100.00%,组间均差异有统计学意义(均P0.05)。4随访病例中,随着PDCD5表达的增强,患者生存评分呈增高趋势(P0.05);而随着Bcl-2表达的减弱,患者生存评分增高(P0.05)。结论:PDCD5蛋白的失活和Bcl-2蛋白的诱导可能与SNSCC的发生、发展密切相关,PDCD5有望为SNSCC的诊疗提供新的靶点。
[Abstract]:Objective: to investigate the expression and clinical significance of programmed cell death factor 5 (PDCD5) and Bcl-2 protein in (SNSCC) of nasal cavity and sinus squamous cell carcinoma. Methods: 46 cases of SNSCC tissues (SNSCC group) and 38 cases of nasal cavity were detected by immunohistochemical SP method and Western blot technique respectively. Expression of PDCD5 and Bcl-2 protein in inverted papilloma of paranasal sinuses (SNIP group) and 20 normal nasal mucosa (normal group). Results: 1Compared with SNIP group and normal group, the expression of PDCD5 protein in SNSCC group was down-regulated and the expression of Bcl-2 protein was up-regulated. 2 in the SNSCC group, the positive expression rates of PDCD5 protein and Bcl-2 protein in the high, middle and low differentiation groups were 100.00and 83.333.3338.89% and 50.0070.83%, respectively. The difference between the two groups was statistically significant (P0.05). 4 in the follow-up cases, with the increase of PDCD5 expression, the survival score of the patients showed an increasing trend (P0.05). With the decrease of Bcl-2 expression, the survival score increased (P0.05). Conclusion: the inactivation of PDCD5 protein and the induction of Bcl-2 protein may be closely related to the occurrence and development of SNSCC. PDCD5 is expected to provide a new target for the diagnosis and treatment of SNSCC.
【作者单位】：承德医学院附属医院耳鼻咽喉科;首都医科大学附属同仁医院耳鼻咽喉头颈外科;宽城县医院耳鼻咽喉科;
【分类号】：R739.62

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