青光眼视网膜神经纤维层厚度变化及其与视野缺损的相关性

发布时间：2018-11-22 16:06

【摘要】：目的利用光学相干断层扫描(optical coherence tomography,OCT)检测早期原发性开角型青光眼和可疑青光眼患者视网膜神经纤维层(retinal nerve fiber layer,RNFL)厚度的变化,并分析其与视野缺损的相关性。方法收集来我院就诊的可疑青光眼患者35例(63眼)为A组,早期原发性开角型青光眼患者41例(72眼)为B组,对照组34例(66眼)为C组,采用OCT仪和Humphrey740i全自动视野计分别对3组受检者进行视盘周围RN-FL厚度和视野检测,比较3组患者的RNFL厚度,分析青光眼组RNFL厚度与视野缺损间的关系。结果 A组的上方、下方象限及平均RNFL厚度与C组对应象限比较,差异均有统计学意义(均为P0.05);B组与C组比较平均及各象限RNFL厚度差异均有统计学意义(均为P0.05);A组与B组比较上方、下方、鼻侧象限及平均RNFL厚度差异均有统计学意义(均为P0.05)。三组受检者各象限及全周视野缺损两两比较,差异均有统计学意义(均为P0.05)。B组平均及各象限RNFL厚度与视野缺损程度均呈负相关(均为P0.05)。结论青光眼患者RNFL厚度变薄,并且与视野缺损程度呈负相关。
[Abstract]:Objective to detect the thickness of retinal nerve fiber layer (retinal nerve fiber layer,RNFL) in patients with primary open angle glaucoma and suspected glaucoma by optical coherence tomography (optical coherence tomography,OCT), and to analyze the correlation between the thickness of retinal nerve fiber layer and visual field defect. Methods 35 cases (63 eyes) of suspected glaucoma in our hospital were collected as group A, 41 cases (72 eyes) as group B and 34 cases (66 eyes) as control group. The perioptic RN-FL thickness and visual field were measured by OCT instrument and Humphrey740i automatic visual field meter respectively. The RNFL thickness of the three groups was compared, and the relationship between RNFL thickness and visual field defect in glaucoma group was analyzed. Results compared with the corresponding quadrant of group C, the upper and lower quadrants and the average thickness of RNFL in group A were significantly different (P0.05). There were significant differences in RNFL thickness between group B and group C (P0.05 between); A group and group B, between group B and group B). There were significant differences in the thickness of RNFL between group B and group C (P0.05). The difference of visual field defect between the three groups was statistically significant (P0.05). B group and each quadrant RNFL thickness were negatively correlated with the degree of visual field defect (P0.05). Conclusion the thickness of RNFL in glaucoma patients is thinned and negatively correlated with the degree of visual field defect.
【作者单位】：赣南医学院第一附属医院眼科;
【基金】：江西省科技厅科技支撑项目基金资助(编号:20122BBG70156-2) 江西省教育厅科技项目基金资助(编号:GJJ13692) 江西省卫生厅科技计划项目基金资助(编号:20133108)~~
【分类号】：R775

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