高强度聚焦超声治疗变应性鼻炎远期疗效的临床研究

发布时间：2018-11-24 08:09

【摘要】：目的观察鼻内窥镜下高强度聚焦超声(HIFU)治疗变应性鼻炎的远期疗效。方法将300例药物治疗无效的变应性鼻炎患者分为治疗组(n=162)及对照组(n=138)。治疗组患者在鼻内窥镜下进行HIFU治疗,对照组患者进行低温等离子消融治疗。两组患者术后随访,采用视觉模拟评分(VAS)于术后3、6、12、24个月进行疗效评定。自愿接受鼻腔纤毛功能检查的两组患者于治疗开始时和治疗结束时行糖精试验,评价其鼻黏膜纤毛功能。结果两组患者治疗2周后鼻塞、喷嚏、流涕、鼻痒等症状均明显缓解,无明显并发症。随访2年治疗组患者的总有效率(61.4%),明显高于对照组(50.7%),差异有统计学意义(P=0.017);治疗组患者(n=49)及对照组患者(n=39)的糖精清除时间平均值分别为(464±152)、(738±149)s,差异有统计学意义(P=0.026)。结论 HIFU治疗变应性鼻炎的远期疗效优于低温等离子消融治疗,并且对鼻黏膜纤毛功能影响更小。
[Abstract]:Objective to observe the long-term efficacy of high intensity focused ultrasound (HIFU) under nasal endoscope in the treatment of allergic rhinitis. Methods 300 patients with allergic rhinitis were divided into treatment group (n = 162) and control group (n = 138). The patients in the treatment group were treated with HIFU under nasal endoscope, and the patients in the control group were treated with hypothermic plasma ablation. Visual analogue score (VAS) was used to evaluate the curative effect of the two groups at 12 and 24 months after operation. The nasal mucosal cilium function was evaluated by saccharin test at the beginning of treatment and at the end of treatment. Results after 2 weeks of treatment, nasal congestion, sneezing, runny nose and itching were relieved obviously in both groups, and no obvious complications were found. The total effective rate in the treatment group (61.4%) was significantly higher than that in the control group (50.7%), and the difference was statistically significant (P0. 017). The mean time of saccharin clearance in the treatment group (nong49) and the control group (nnm39) was (464 卤152), (738 卤149) s, the difference was statistically significant (P0. 026). Conclusion the long term effect of HIFU on allergic rhinitis is better than that of low temperature plasma ablation and has less effect on nasal mucosal cilium function.
【作者单位】：重庆医科大学附属第一医院耳鼻喉科;
【基金】：国家临床重点专科建设项目(卫办医政函[2012]649号)
【分类号】：R765.21

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