喉癌患者喉部分切除术后感染调查研究

发布时间：2018-11-28 19:59

【摘要】：目的探讨喉癌患者喉部分切除术后感染的临床特点,为喉癌患者手术治疗提供支持。方法回顾性分析2000年12月-2008年12月394例行手术的喉癌患者临床资料,调查统计术后感染分布、感染病菌种类、病原菌耐药性和术后病死率。结果喉癌术后感染率为16.8%;术后感染分布主要为肺部感染、切口感染、咽瘘、褥疮、泌尿系统,以肺部感染为主,感染率为48.5%;术后感染革兰阴性菌为主,占59.2%;铜绿假单胞菌和肺炎克雷伯菌对亚胺培南和美罗培南耐药性极低,耐药率分别为0和5.0%、15.0%和0;金黄色葡萄球菌和溶血葡萄球菌对万古霉素耐药性极低,耐药率均为0;术后3个月内病死率为15.2%(P0.05),术后3个月至5年病死率为16.1%,差异无统计学意义。结论术后感染率较高,对术后感染者及时做细菌培养和药敏试验,指导临床合理用药,降低病死率。
[Abstract]:Objective to investigate the clinical features of partial laryngectomy infection in patients with laryngeal cancer and to provide support for surgical treatment of laryngeal cancer. Methods the clinical data of 394 patients with laryngeal cancer from December 2000 to December 2008 were analyzed retrospectively. The distribution of infection, the types of infection bacteria, the drug resistance of pathogens and the postoperative mortality were investigated. Results the postoperative infection rate of laryngeal carcinoma was 16.8.The distribution of postoperative infection was mainly pulmonary infection, incision infection, pharyngeal fistula, bedsore, urinary system, mainly pulmonary infection, infection rate was 48.5%. The resistance of Pseudomonas aeruginosa and Klebsiella pneumoniae to imipenem and meropenem were very low, the resistance rates were 0 and 5.0%, respectively. The resistance of Staphylococcus aureus and Staphylococcus haemolyticus to vancomycin was very low, and the resistance rate was 0. The mortality within 3 months after operation was 15.2% (P0.05), and the fatality rate of 3 months to 5 years after operation was 16.1.The difference was not statistically significant. Conclusion the infection rate after operation is high. The bacterial culture and drug sensitivity test should be done in time to guide the rational use of drugs and reduce the mortality.
【作者单位】：山东省潍坊医学院附属医院耳鼻咽喉科;
【基金】：山东省自然科学基金资助项目(ZR2009DZ004)
【分类号】：R739.65

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