达明饮联合羟苯磺酸钙治疗非增殖期糖尿病视网膜病变的临床研究

发布时间：2018-12-15 00:11

【摘要】：目的：观察达明饮联合羟苯磺酸钙治疗非增殖期糖尿病视网膜病变的临床疗效,探讨其可能的作用机制。方法：观察NPDR患者36例(67眼),随机分为治疗组17例(32眼)和对照组19例(35眼)。治疗组口服中药达明饮及羟苯磺酸钙,对照组口服羟苯磺酸钙,连续服用30天。观察服药前后视力、眼底、眼底荧光血管造影、血流变及血脂的变化。结果：(1).视力检查比较,两组自身治疗前后对比有统计学意义(P0.05),用药后组间比较有统计学意义(P0.05)。表明两组均能提高DR患者的视力,治疗组优于对照组。(2).眼底荧光血管造影比较,治疗组总有效率为94.7%,对照组总有效率为74.3%,治疗后组间比较有统计学意义(P0.05),表明两组眼底明可以明显改善患者的眼底,且治疗组优于对照组。(3)血液流变学及血脂的比较,自身治疗前后对比有统计学意义(P0.05),治疗后组间比较有显著差异(P0.01或P0.05),表明两组均能改善血液流变学,降低血脂,治疗组改善血液流变学及血脂优于对照组。结论：达明饮联合羟苯磺酸钙治疗NPDR,能提高视力,改善视网膜微循环；联合用药明显优于单用羟苯磺酸钙的疗效；作用机制可能与改善血液流变学及血脂、改善眼底微循环,提高视网膜对缺血缺氧的耐受性有关。
[Abstract]:Objective: to observe the clinical effect of Daming decoction combined with calcium dobesilate in the treatment of non proliferative diabetic retinopathy and explore its possible mechanism. Methods: 36 patients (67 eyes) with NPDR were randomly divided into treatment group (n = 17) and control group (n = 19) (35 eyes). The treatment group took Daming decoction and calcium dobesilate, while the control group took calcium dobesilate for 30 days. The changes of visual acuity, fundus fluorescein angiography, hemorheology and blood lipid were observed. Results: (1). The visual acuity of the two groups before and after treatment was statistically significant (P0.05), and the comparison between the two groups was statistically significant after medication (P0.05). The results showed that both groups could improve the visual acuity of DR patients, and the treatment group was superior to the control group. (2). Fundus fluorescein angiography showed that the total effective rate in the treatment group was 94.77.The total effective rate in the control group was 74.3. There was significant difference between the two groups after treatment (P0.05). And the treatment group is better than the control group. (3) the comparison of hemorheology and blood lipid was statistically significant before and after treatment (P0.05), and there was significant difference between the groups after treatment (P0.01 or P0.05). The results showed that both groups could improve hemorheology and reduce blood lipids, while the treatment group was superior to the control group in improving hemorheology and blood lipids. Conclusion: Daming decoction combined with calcium dobesilate can improve visual acuity and improve retinal microcirculation in NPDR, and the combined therapy is better than calcium dobesilate alone. The mechanism may be related to the improvement of hemorheology and blood lipid, the improvement of fundus microcirculation and the tolerance of retina to ischemia and hypoxia.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R774.1

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