质子泵抑制剂治疗咽喉反流患者声嘶症状的疗效观察

发布时间：2018-12-18 18:23

【摘要】：目的:探讨质子泵抑制剂(PPI)治疗咽喉反流(LPR)患者声嘶症状的疗效。方法:60例以声嘶为主诉LPR患者,随机分为A、B两组:A组(30例)给予金嗓开音胶囊治疗(1.2g/次,2次/d,口服,连用3个月);B组(30例)在A组的基础上同时加用奥美拉唑治疗(20mg/次,2次/d,口服,连用3个月)。在治疗前和治疗后1、2、3个月分别记录以下数据:反流症状指数(RSI),反流体征指数(RFS)和嗓音障碍指数(VHI),比较A、B两组上述参数变化的差异。结果:60例患者治疗前RSI和RFS分别与VHI评分比较,均呈显著正相关(r=0.823,P0.01;r=0.873,P0.01)。与治疗前相比,B组治疗后1、2、3个月的RSI和VHI的评分变化显著高于A组,差异有统计学意义(P0.01)。B组治疗后1、2个月的RFS评分与A组比较差异无统计学意义(t=1.128,P0.05;t=0.376,P0.05),但治疗后3个月RFS评分显著高于A组(t=8.307,P0.01)。结论:PPI治疗可显著改善LPR患者的声嘶症状。
[Abstract]:Objective: to evaluate the efficacy of proton pump inhibitor (PPI) in the treatment of hoarseness in patients with pharyngeal reflux (LPR). Methods: sixty patients with hoarseness were randomly divided into two groups: group A (30 cases) were treated with Jinsang Kaiyin capsule (1.2g/ twice a day, orally for 3 months); Group B (30 cases) was treated with omeprazole on the basis of group A (20mg/ twice a day, orally for 3 months). The following data were recorded before treatment and at 1: 2 and 3 months after treatment: reflux symptom index (RSI), reflux sign index (RFS), and voice disorder index (VHI),) were compared with those in group A (group B). Results: there was a significant positive correlation between RSI and RFS and VHI scores in 60 patients before treatment (r = 0.823, P 0.01, P = 0.873P 0.01). The scores of RSI and VHI in group B were significantly higher than those in group A at 1 and 3 months after treatment compared with those before treatment. The difference was statistically significant (P0.01). B group had no significant difference in RFS score at 1 and 2 months after treatment compared with group A (t = 1.128). P0.05; The RFS score of group A was significantly higher than that of group A at 3 months after treatment (t = 8.307, P0.01). Conclusion: PPI can significantly improve the hoarseness of LPR patients.
【作者单位】：西安交通大学第二附属医院耳鼻咽喉头颈外科病院;
【分类号】：R766

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