喉癌中MTA1分布特点及其与MMP-9、VEGF-C蛋白表达的相关性分析

发布时间：2019-01-30 13:20

【摘要】：目的研究肿瘤转移相关基因1(MTA1)蛋白在喉癌组织中的表达特点,并分析其与基质金属蛋白酶9(MMP-9)、血管内皮生长因子C(VEGF-C)蛋白的相关性。方法采用Western blot法检测40例喉癌患者的正常喉黏膜组织、癌周围组织及肿瘤组织样本中MTA1、MMP-9、VEGF-C蛋白表达,并统计分析其临床病理特性。结果与喉癌无颈淋巴结转移组、癌周围及正常组织相比,喉癌颈淋巴结转移组中MTA1蛋白的表达水平明显升高(P0.05)。MTA1蛋白在喉癌组织中的表达与淋巴结转移、肿瘤分期及肿瘤分化程度呈正相关(P0.05),并与VEGF-C、MMP-9表达正相关(P0.05)。结论 MTA1可能参与喉癌的发生、发展和转移,且可能与MMP-9、VEGF-C蛋白之间存在调控作用。
[Abstract]:Objective to study the expression of tumor metastasis associated gene 1 (MTA1) in laryngeal carcinoma and to analyze its correlation with matrix metalloproteinase-9 (MMP-9) and vascular endothelial growth factor C (VEGF-C) protein. Methods Western blot method was used to detect the expression of MTA1,MMP-9,VEGF-C protein in the normal laryngeal mucosa, surrounding tissues and tumor tissues of 40 patients with laryngeal carcinoma, and its clinicopathological characteristics were statistically analyzed. Results the expression level of MTA1 protein in cervical lymph node metastasis group was significantly higher than that in laryngeal carcinoma without cervical lymph node metastasis group, pericancerous group and normal tissue (P0.05). The expression of MTA1 protein in laryngeal carcinoma tissue and lymph node metastasis was significantly higher than that in laryngeal carcinoma without cervical lymph node metastasis group (P0.05). Tumor stage and tumor differentiation were positively correlated (P0.05), and positively correlated with VEGF-C,MMP-9 expression (P0.05). Conclusion MTA1 may be involved in the occurrence, development and metastasis of laryngeal carcinoma, and may play a regulatory role with MMP-9,VEGF-C protein.
【作者单位】：重庆市第九人民医院耳鼻喉科;重庆医科大学附属第一医院耳鼻喉科;重庆医科大学附属第一医院神经病学重点实验室;
【分类号】：R739.65

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