鼻咽癌高发区人群患鼻咽癌风险率的动态观察

发布时间：2019-02-08 18:04

【摘要】：目的:了解高发区人群鼻咽癌患病风险率的变化情况,对筛查间隔的时间做出评估,提高鼻咽癌筛查效益。方法:中山市人民医院肿瘤研究所2009-07-01-2012-08-01连续3年在中山市小榄镇进行鼻咽癌筛查,收集连续3年参加EB病毒抗体检测的613人的血清学资料,根据EB病毒抗体VCA/IgA和NA1/IgA计算人群的患鼻咽癌风险率,并分析人群患鼻咽癌风险率的3年动态变化情况。结果:中、高危人群所占比例由66.72%下降至40.13%,低危人群的比例由33.28%上升至59.87%。2010-2011年高危人群持续高危率为64.91%,高危人群转低危率为5.26%;中危人群转高危率为38.64%,中危人群转转低危率为15.91%。低危人群转高危率为7.84%。2011-2012年高危人群持续高危率为34.39%,高危人群转低危率为35.45%;中危人群转高危率为9.33%,中危人群转转低危率为57.33%;低危人群转高危率为5.03%。人群持续高危率、中危或低危转高危率均降低,P0.001,而高危、中危人群转低危率上升,P0.001。整体人群在随访中未检出新发鼻咽癌。结论:在初筛后2年内,人群中较高患鼻咽癌风险率的人群减少,对整体人群没必要进行不间隔的连续随访。
[Abstract]:Objective: to investigate the risk rate of nasopharyngeal carcinoma (NPC) in high incidence population and to evaluate the interval between screening and to improve the effectiveness of NPC screening. Methods: the Institute of Oncology, Zhongshan people's Hospital, 2009-07-01-2012-08-01, was screened for nasopharyngeal carcinoma in Xiaolan Town, Zhongshan City for 3 consecutive years. The serological data of 613 people who participated in the detection of EB virus antibody for 3 consecutive years were collected. The risk rate of nasopharyngeal carcinoma was calculated according to EB virus antibody VCA/IgA and NA1/IgA, and the dynamic changes of NPC risk rate in population were analyzed. Results: the proportion of high risk group decreased from 66.72% to 40.13%, and the proportion of low risk group increased from 33.28% to 59.87.The persistent high risk rate of high risk group in 2010-2011 was 64.91%. The risk rate of high risk group was 5.26; The rate of transition from moderate to high risk was 38.64, and from moderate to low was 15.91. The rate of transition from low risk group to high risk group was 7.84. In 2011-2012, the continuous high risk rate of high risk group was 34.39, the transition rate of high risk group to low risk group was 35.4545, the transition rate of middle risk group to high risk group was 9.33, the transition rate of middle risk group to low risk group was 57.33. The transition rate of low risk group to high risk group was 5.03. The rate of continuous high risk, moderate or low risk to high risk decreased (P 0.001), while the rate of high risk, middle risk to low risk increased (P 0.001). No new nasopharyngeal carcinoma was detected during follow-up. Conclusion: within 2 years after screening, the population with higher risk of nasopharyngeal carcinoma was reduced, and there was no need for continuous follow-up of the whole population.
【作者单位】：中山市人民医院;中山大学附属中山医院肿瘤研究所;中山大学肿瘤防治中心华南肿瘤学国家重点实验室;
【基金】：“十一·五”国家科技支撑计划(2006BAI02A11) 中央补助地方卫生专项癌症早诊早治专项资金
【分类号】：R739.63

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