早期青光眼不同类型视盘视网膜神经纤维层厚度分析

发布时间：2019-03-17 14:53

【摘要】：目的探讨早期青光眼患者不同类型视盘的视网膜神经纤维层(retinal nerve fiber layer,RNFL)厚度,以了解不同类型视盘的早期青光眼患者的RNFL厚度的特点。方法应用光学相干断层扫描(optical coherence tomography,OCT)技术检查视盘RNFL厚度,将收集到的OCT视盘检查结果分为6组:对照组大视盘组、中视盘组、小视盘组,每组各20眼,早期青光眼大视盘组、中视盘组、小视盘组各20眼。OCT测量120眼各钟点平均RNFL厚度。检测对照组和早期青光眼患者12个钟位的视盘RNFL厚度。结果对照组不同类型视盘组的RNFL厚度曲线均在下方和上方形成双峰,在鼻侧和颞侧形成波谷,各组下方峰均高于上方峰。其中大视盘组患者RNFL厚度(105.60±5.87)μm,其次是中视盘组(107.05±7.29)μm和小视盘组(108.40±7.27)μm。对照组大、中、小视盘组的RNFL厚度差异无统计学意义(P0.05)。早期青光眼RNFL厚度曲线的上或下方峰值降低,但仍然具备上、下方的双峰特征,各组的下方峰皆高于上方峰。其中大视盘组患者RNFL厚度最薄(70.25±14.71)μm,其次是中视盘组(85.55±15.39)μm和小视盘组(87.55±9.46)μm,大视盘组与中视盘组、小视盘组的视盘RNFL厚度的差异有统计学意义(均为P0.05),中视盘组与小视盘组的RNFL厚度差异无统计学意义(P0.05)。早期青光眼患者与对照组不同类型视盘的RNFL均为厚度差异均有统计学意义(均为P0.05)。结论对照组不同大小的视盘并不影响RNFL厚度,早期青光眼患者视盘的RNFL厚度明显变薄,但仍然具备上、下方的双峰特征,各组的下方峰皆高于上方峰,其中大视盘患者的RNFL比中、小视盘受损更严重。
[Abstract]:Objective to investigate the thickness of retinal nerve fiber layer (retinal nerve fiber layer,RNFL) of different types of optic disc in patients with early glaucoma, so as to understand the characteristics of RNFL thickness in patients with different types of optic disc. Methods the optical coherence tomography (optical coherence tomography,OCT) technique was used to examine the RNFL thickness of optic disc. The results of OCT disc examination were divided into 6 groups: large optic disc group, middle optic disc group, small optic disc group, 20 eyes in each group, and 20 eyes in each group. The average RNFL thickness was measured by Oct in 20 eyes of the large optic disc group, 20 eyes of the middle optic disc group and 20 eyes of the small optic disc group. The RNFL thickness of optic disc was measured at 12 hours in control group and early glaucoma patients. Results the RNFL thickness curves of the different types of optic disc group in the control group formed double peaks below and above, and the nasal and temporal valleys were formed in the nasal and temporal sides. The lower peaks in each group were higher than those in the upper ones. The thickness of RNFL was (105.60 卤5.87) 渭 m in the large disc group, (107.05 卤7.29) 渭 m in the middle optic disk group and (108.40 卤7.27) 渭 m in the small disc group. There was no significant difference in the thickness of RNFL between the large, medium and small disc groups in the control group (P0.05). The upper and lower peaks of RNFL thickness curve in early glaucoma decreased, but they still had the characteristics of upper and lower double peaks. The lower peak was higher than the upper peak in each group. The thickness of RNFL was the thinnest (70.25 卤14.71) 渭 m in the large disc group, (85.55 卤15.39) 渭 m in the middle optic disk group, (87.55 卤9.46) 渭 m in the small optic disk group, (87.55 卤9.46) 渭 m in the small optic disk group, and (70.25 卤14.71) 渭 m in the large optic disk group and in the middle optic disk group. There was significant difference in the thickness of RNFL between the small disc group and the small disc group (P 0.05), but there was no significant difference in the RNFL thickness between the medium disc group and the small disc group (P0.05). The RNFL thickness of different types of optic disc in patients with early glaucoma was significantly different from that in control group (P 0.05). Conclusion the optic disc of different sizes in the control group has no effect on the thickness of RNFL. The thickness of RNFL in the optic disc of early glaucoma patients is obviously thinner, but it still has the characteristics of upper and lower double peaks, and the lower peak of each group is higher than the upper peak. The RNFL of the patients with large disc was more severe than that of the small disc.
【作者单位】：首都医科大学附属北京朝阳医院眼科;
【分类号】：R775

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